NF GEMMs Already! The Power and Promise of Mouse Tumor Models

David H. Gutmann

doi:10.1016/j.ccell.2014.10.007

NF GEMMs Already! The Power and Promise of Mouse Tumor Models

David H. Gutmann

Research output: Contribution to journal › Short survey › peer-review

3 Scopus citations

Abstract

Plexiform neurofibromas are one of the most common tumors encountered in individuals with the neurofibromatosis type I (NF1) cancer predisposition syndrome. In this issue of Cancer Cell, Chen and colleagues define the cell of origin for murine Nf1 plexiform neurofibroma and leverage this finding to develop a platform for preclinical drug evaluation. Plexiform neurofibromas are one of the most common tumors encountered in individuals with the neurofibromatosis type I (NF1) cancer predisposition syndrome. In this issue of Cancer Cell, Chen and colleagues define the cell of origin for murine Nf1 plexiform neurofibroma and leverage this finding to develop a platform for preclinical drug evaluation.

Original language	English
Pages (from-to)	596-599
Number of pages	4
Journal	Cancer Cell
Volume	26
Issue number	5
DOIs	https://doi.org/10.1016/j.ccell.2014.10.007
State	Published - Nov 10 2014

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10.1016/j.ccell.2014.10.007

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title = "NF GEMMs Already! The Power and Promise of Mouse Tumor Models",

abstract = "Plexiform neurofibromas are one of the most common tumors encountered in individuals with the neurofibromatosis type I (NF1) cancer predisposition syndrome. In this issue of Cancer Cell, Chen and colleagues define the cell of origin for murine Nf1 plexiform neurofibroma and leverage this finding to develop a platform for preclinical drug evaluation. Plexiform neurofibromas are one of the most common tumors encountered in individuals with the neurofibromatosis type I (NF1) cancer predisposition syndrome. In this issue of Cancer Cell, Chen and colleagues define the cell of origin for murine Nf1 plexiform neurofibroma and leverage this finding to develop a platform for preclinical drug evaluation.",

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AU - Gutmann, David H.

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N2 - Plexiform neurofibromas are one of the most common tumors encountered in individuals with the neurofibromatosis type I (NF1) cancer predisposition syndrome. In this issue of Cancer Cell, Chen and colleagues define the cell of origin for murine Nf1 plexiform neurofibroma and leverage this finding to develop a platform for preclinical drug evaluation. Plexiform neurofibromas are one of the most common tumors encountered in individuals with the neurofibromatosis type I (NF1) cancer predisposition syndrome. In this issue of Cancer Cell, Chen and colleagues define the cell of origin for murine Nf1 plexiform neurofibroma and leverage this finding to develop a platform for preclinical drug evaluation.

AB - Plexiform neurofibromas are one of the most common tumors encountered in individuals with the neurofibromatosis type I (NF1) cancer predisposition syndrome. In this issue of Cancer Cell, Chen and colleagues define the cell of origin for murine Nf1 plexiform neurofibroma and leverage this finding to develop a platform for preclinical drug evaluation. Plexiform neurofibromas are one of the most common tumors encountered in individuals with the neurofibromatosis type I (NF1) cancer predisposition syndrome. In this issue of Cancer Cell, Chen and colleagues define the cell of origin for murine Nf1 plexiform neurofibroma and leverage this finding to develop a platform for preclinical drug evaluation.

UR - https://www.scopus.com/pages/publications/84912064721

U2 - 10.1016/j.ccell.2014.10.007

DO - 10.1016/j.ccell.2014.10.007

M3 - Short survey

C2 - 25517743

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SN - 1535-6108

VL - 26

SP - 596

EP - 599

JO - Cancer Cell

JF - Cancer Cell

IS - 5

ER -

NF GEMMs Already! The Power and Promise of Mouse Tumor Models

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