TY - JOUR
T1 - Next-generation approaches to understand and combat the antibiotic resistome
AU - Crofts, Terence S.
AU - Gasparrini, Andrew J.
AU - Dantas, Gautam
N1 - Funding Information:
This work was supported, in part, by awards to G.D. through the Edward Mallinckrodt Jr. Foundation (Scholar Award), and from the US National Institutes of Health (NIH) Director's New Innovator Award (http://commonfund.nih.gov/newinnovator/), the National Institute of Diabetes and Digestive and Kidney Diseases (http://www.niddk.nih.gov/), the National Institute of General Medical Sciences (NIGMS; http://www.nigms.nih.gov/) and the National Institute of Allergy and Infectious Diseases (https://www.niaid.nih.gov/) of the NIH under award numbers DP2DK098089, R01GM099538 and R01AI123394, respectively. T.S.C. received support from a National Institute of Child Health and Development training grant through award number T32 HD049305 (K. H. Moley is named as the Principal Investigator on this grant). A.J.G. received support from a NIGMS training grant through award number T32 GM007067 (J. Skeath is named as the Principal Investigator on this grant). The content of this Review is solely the responsibility of the authors and does not necessarily represent the official views of the funding agencies.
Publisher Copyright:
© 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.
PY - 2017/6/13
Y1 - 2017/6/13
N2 - Antibiotic resistance is a natural feature of diverse microbial ecosystems. Although recent studies of the antibiotic resistome have highlighted barriers to the horizontal transfer of antibiotic resistance genes between habitats, the rapid global spread of genes that confer resistance to carbapenem, colistin and quinolone antibiotics illustrates the dire clinical and societal consequences of such events. Over time, the study of antibiotic resistance has grown from focusing on single pathogenic organisms in axenic culture to studying antibiotic resistance in pathogenic, commensal and environmental bacteria at the level of microbial communities. As the study of antibiotic resistance advances, it is important to incorporate this comprehensive approach to better inform global antibiotic resistance surveillance and antibiotic development. It is increasingly becoming apparent that although not all resistance genes are likely to geographically and phylogenetically disseminate, the threat presented by those that are is serious and warrants an interdisciplinary research focus. In this Review, we highlight seminal work in the resistome field, discuss recent advances in the studies of resistomes, and propose a resistome paradigm that can pave the way for the improved proactive identification and mitigation of emerging antibiotic resistance threats.
AB - Antibiotic resistance is a natural feature of diverse microbial ecosystems. Although recent studies of the antibiotic resistome have highlighted barriers to the horizontal transfer of antibiotic resistance genes between habitats, the rapid global spread of genes that confer resistance to carbapenem, colistin and quinolone antibiotics illustrates the dire clinical and societal consequences of such events. Over time, the study of antibiotic resistance has grown from focusing on single pathogenic organisms in axenic culture to studying antibiotic resistance in pathogenic, commensal and environmental bacteria at the level of microbial communities. As the study of antibiotic resistance advances, it is important to incorporate this comprehensive approach to better inform global antibiotic resistance surveillance and antibiotic development. It is increasingly becoming apparent that although not all resistance genes are likely to geographically and phylogenetically disseminate, the threat presented by those that are is serious and warrants an interdisciplinary research focus. In this Review, we highlight seminal work in the resistome field, discuss recent advances in the studies of resistomes, and propose a resistome paradigm that can pave the way for the improved proactive identification and mitigation of emerging antibiotic resistance threats.
UR - http://www.scopus.com/inward/record.url?scp=85017121755&partnerID=8YFLogxK
U2 - 10.1038/nrmicro.2017.28
DO - 10.1038/nrmicro.2017.28
M3 - Review article
C2 - 28392565
AN - SCOPUS:85017121755
SN - 1740-1526
VL - 15
SP - 422
EP - 434
JO - Nature Reviews Microbiology
JF - Nature Reviews Microbiology
IS - 7
ER -