NeXO Web: The NeXO ontology database and visualization platform

Janusz Dutkowski; Keiichiro Ono; Michael Kramer; Michael Yu; Dexter Pratt; Barry Demchak; Trey Ideker

doi:10.1093/nar/gkt1192

NeXO Web: The NeXO ontology database and visualization platform

Janusz Dutkowski, Keiichiro Ono, Michael Kramer, Michael Yu, Dexter Pratt, Barry Demchak, Trey Ideker

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

The Network-extracted Ontology (NeXO) is a gene ontology inferred directly from large-scale molecular networks. While most ontologies are constructed through manual expert curation, NeXO uses a principled computational approach which integrates evidence from hundreds of thousands of individual gene and protein interactions to construct a global hierarchy of cellular components and processes. Here, we describe the development of the NeXO Web platform (http://www.nexontology.org) - an online database and graphical user interface for visualizing, browsing and performing term enrichment analysis using NeXO and the gene ontology. The platform applies state-of-the-art web technology and visualization techniques to provide an intuitive framework for investigating biological machinery captured by both data-driven and manually curated ontologies.

Original language	English
Pages (from-to)	D1269-D1274
Journal	Nucleic acids research
Volume	42
Issue number	D1
DOIs	https://doi.org/10.1093/nar/gkt1192
State	Published - Jan 1 2014

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AU - Pratt, Dexter

AU - Demchak, Barry

AU - Ideker, Trey

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NeXO Web: The NeXO ontology database and visualization platform

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