New roles revealed for T cells and DCs in glomerulonephritis.

Alfred H.J. Kim; Mary A. Markiewicz; Andrey S. Shaw

doi:10.1172/jci39071

New roles revealed for T cells and DCs in glomerulonephritis.

Alfred H.J. Kim, Mary A. Markiewicz, Andrey S. Shaw

Research output: Contribution to journal › Comment/debate

11 Scopus citations

Abstract

Little is known about the potential role of T cells in the inflammatory renal disease glomerulonephritis (GN). GN has been historically viewed as a product of immune complex-mediated complement activation, and the presence of autoantibodies made identifying T cell-specific effector contributions difficult to elucidate. In this issue of the JCI, Heymann et al. generate what they believe to be a novel, transgenic murine model of GN, demonstrating a direct role for CD8+ T cells, activated CD4+ T cells, and DCs in the pathogenesis of GN (see the related article beginning on page 1286).

Original language	English
Pages (from-to)	1074-1076
Number of pages	3
Journal	The Journal of clinical investigation
Volume	119
Issue number	5
DOIs	https://doi.org/10.1172/jci39071
State	Published - May 2009

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title = "New roles revealed for T cells and DCs in glomerulonephritis.",

abstract = "Little is known about the potential role of T cells in the inflammatory renal disease glomerulonephritis (GN). GN has been historically viewed as a product of immune complex-mediated complement activation, and the presence of autoantibodies made identifying T cell-specific effector contributions difficult to elucidate. In this issue of the JCI, Heymann et al. generate what they believe to be a novel, transgenic murine model of GN, demonstrating a direct role for CD8+ T cells, activated CD4+ T cells, and DCs in the pathogenesis of GN (see the related article beginning on page 1286).",

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AU - Markiewicz, Mary A.

AU - Shaw, Andrey S.

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N2 - Little is known about the potential role of T cells in the inflammatory renal disease glomerulonephritis (GN). GN has been historically viewed as a product of immune complex-mediated complement activation, and the presence of autoantibodies made identifying T cell-specific effector contributions difficult to elucidate. In this issue of the JCI, Heymann et al. generate what they believe to be a novel, transgenic murine model of GN, demonstrating a direct role for CD8+ T cells, activated CD4+ T cells, and DCs in the pathogenesis of GN (see the related article beginning on page 1286).

AB - Little is known about the potential role of T cells in the inflammatory renal disease glomerulonephritis (GN). GN has been historically viewed as a product of immune complex-mediated complement activation, and the presence of autoantibodies made identifying T cell-specific effector contributions difficult to elucidate. In this issue of the JCI, Heymann et al. generate what they believe to be a novel, transgenic murine model of GN, demonstrating a direct role for CD8+ T cells, activated CD4+ T cells, and DCs in the pathogenesis of GN (see the related article beginning on page 1286).

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JF - The Journal of clinical investigation

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ER -

New roles revealed for T cells and DCs in glomerulonephritis.

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