TY - JOUR
T1 - New platinum(II)-bipyridyl corrole complexes
T2 - Synthesis, characterization and binding studies with DNA and HSA
AU - Iglesias, Bernardo A.
AU - Barata, Joana F.B.
AU - Pereira, Patrícia M.R.
AU - Girão, Henrique
AU - Fernandes, Rosa
AU - Tomé, João P.C.
AU - Neves, Maria G.P.M.S.
AU - Cavaleiro, José A.S.
N1 - Publisher Copyright:
© 2015 Elsevier Inc. All rights reserved.
PY - 2015/12/1
Y1 - 2015/12/1
N2 - A simple methodology giving access to the metal-free corroles of trans-A2B type, 5,15-bis(pentafluorophenyl)-10-{3-[2-(pyridin-4-yl)vinyl]phenyl}corrole and 5,15-bis(pentafluorophenyl)-10-{4-[2-(pyridin-4-yl)vinyl]phenyl}corrole, and to the corresponding bipyridyl platinum(II) complexes is described. These new positional isomers were fully characterized and spectroscopic studies demonstrated the ability of Pt(II)-corrole complexes to establish non-covalent interactions with calf-thymus DNA (ct-DNA) and human serum albumin (HSA). Additionally, gel electrophoresis experiments demonstrated that Pt(II)-corrole complexes are able to bind plasmid pMT123 DNA, inducing alterations on its secondary structure.
AB - A simple methodology giving access to the metal-free corroles of trans-A2B type, 5,15-bis(pentafluorophenyl)-10-{3-[2-(pyridin-4-yl)vinyl]phenyl}corrole and 5,15-bis(pentafluorophenyl)-10-{4-[2-(pyridin-4-yl)vinyl]phenyl}corrole, and to the corresponding bipyridyl platinum(II) complexes is described. These new positional isomers were fully characterized and spectroscopic studies demonstrated the ability of Pt(II)-corrole complexes to establish non-covalent interactions with calf-thymus DNA (ct-DNA) and human serum albumin (HSA). Additionally, gel electrophoresis experiments demonstrated that Pt(II)-corrole complexes are able to bind plasmid pMT123 DNA, inducing alterations on its secondary structure.
KW - Corroles
KW - Deoxyribonucleic acid (DNA)
KW - Human serum albumin (HSA)
KW - Plasmid DNA (pDNA)
KW - Platinum(II) complexes
KW - trans-AB corroles
UR - https://www.scopus.com/pages/publications/84942274724
U2 - 10.1016/j.jinorgbio.2015.08.016
DO - 10.1016/j.jinorgbio.2015.08.016
M3 - Article
C2 - 26409160
AN - SCOPUS:84942274724
SN - 0162-0134
VL - 153
SP - 32
EP - 41
JO - Journal of Inorganic Biochemistry
JF - Journal of Inorganic Biochemistry
ER -