New platinum(II)-bipyridyl corrole complexes: Synthesis, characterization and binding studies with DNA and HSA

Bernardo A. Iglesias, Joana F.B. Barata, Patrícia M.R. Pereira, Henrique Girão, Rosa Fernandes, João P.C. Tomé, Maria G.P.M.S. Neves, José A.S. Cavaleiro

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

A simple methodology giving access to the metal-free corroles of trans-A2B type, 5,15-bis(pentafluorophenyl)-10-{3-[2-(pyridin-4-yl)vinyl]phenyl}corrole and 5,15-bis(pentafluorophenyl)-10-{4-[2-(pyridin-4-yl)vinyl]phenyl}corrole, and to the corresponding bipyridyl platinum(II) complexes is described. These new positional isomers were fully characterized and spectroscopic studies demonstrated the ability of Pt(II)-corrole complexes to establish non-covalent interactions with calf-thymus DNA (ct-DNA) and human serum albumin (HSA). Additionally, gel electrophoresis experiments demonstrated that Pt(II)-corrole complexes are able to bind plasmid pMT123 DNA, inducing alterations on its secondary structure.

Original languageEnglish
Pages (from-to)32-41
Number of pages10
JournalJournal of Inorganic Biochemistry
Volume153
DOIs
StatePublished - Dec 1 2015

Keywords

  • Corroles
  • Deoxyribonucleic acid (DNA)
  • Human serum albumin (HSA)
  • Plasmid DNA (pDNA)
  • Platinum(II) complexes
  • trans-AB corroles

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