TY - JOUR
T1 - New insights into the pathophysiology of Parkinson's disease
T2 - the challenge of positron emission tomography
AU - Perlmutter, Joel S.
N1 - Funding Information:
I thank Marcus E. Raichle for helpful comments and the entire staff of the Division of Radiation Scienceso f the Mallinckrodt Institute of Radiolo&y for expert assistance. This work was supported by NIH grants N506833, HL 13851, TeacherI nvestigator Development Award N500929 and the Greater St Louis Chapter of the American Parkinson 's DiseaseA ssociation.
PY - 1988
Y1 - 1988
N2 - Positron emission tomography (PET) permits the quantitative in-vivo measurement of regional brain hemodynamics, metabolism, receptor pharmacology and neurotransmitter metabolism in human subjects. As such, it promised to reveal unique insights into the pathophysiology of brain disorders such as Parkinson's disease. However, preliminary studies of Parkinson's disease have frequently presented conflicting results that seem to obscure, rather than clarify, underlying disease processes. This apparent failure reflects early methodological difficulties; recent technical advances have led to the disclosure of exciting new avenues of investigation.
AB - Positron emission tomography (PET) permits the quantitative in-vivo measurement of regional brain hemodynamics, metabolism, receptor pharmacology and neurotransmitter metabolism in human subjects. As such, it promised to reveal unique insights into the pathophysiology of brain disorders such as Parkinson's disease. However, preliminary studies of Parkinson's disease have frequently presented conflicting results that seem to obscure, rather than clarify, underlying disease processes. This apparent failure reflects early methodological difficulties; recent technical advances have led to the disclosure of exciting new avenues of investigation.
UR - http://www.scopus.com/inward/record.url?scp=0023887217&partnerID=8YFLogxK
U2 - 10.1016/0166-2236(88)90123-3
DO - 10.1016/0166-2236(88)90123-3
M3 - Article
C2 - 2471321
AN - SCOPUS:0023887217
SN - 0166-2236
VL - 11
SP - 203
EP - 208
JO - Trends in Neurosciences
JF - Trends in Neurosciences
IS - 5
ER -