New Insights into the Pathogenesis and Treatment of Malnutrition

Grace E. Thaxton, Peter C. Melby, Mark J. Manary, Geoffrey A. Preidis

Research output: Contribution to journalReview article

Abstract

The volume of research into the pathogenesis and treatment of malnutrition has increased markedly over the past ten years, providing mechanistic insights that can be leveraged into more effective treatment options. These discoveries have been driven by several landmark studies employing metabolomics, metagenomics, and new preclinical models. This review highlights some of the most important recent findings, focusing in particular on the emerging roles of prenatal and perinatal factors, protein deficiency, impaired gut barrier function, immune deficiency, and the intestinal microbiome.

Original languageEnglish
Pages (from-to)813-827
Number of pages15
JournalGastroenterology Clinics of North America
Volume47
Issue number4
DOIs
StatePublished - Dec 2018

Keywords

  • Epigenetics
  • Immune deficiency
  • Intestinal microbiota
  • Perinatal
  • Prenatal
  • Protein deficiency
  • Therapeutic foods
  • Undernutrition

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