New Insights into Mechanism and Regulation of Actin Capping Protein

John A. Cooper, David Sept

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

189 Scopus citations

Abstract

The heterodimeric actin capping protein, referred to here as "CP," is an essential element of the actin cytoskeleton, binding to the barbed ends of actin filaments and regulating their polymerization. In vitro, CP has a critical role in the dendritic nucleation process of actin assembly mediated by Arp2/3 complex, and in vivo, CP is important for actin assembly and actin-based process of morphogenesis and differentiation. Recent studies have provided new insight into the mechanism of CP binding the barbed end, which raises new possibilities for the dynamics of CP and actin in cells. In addition, a number of molecules that bind and regulate CP have been discovered, suggesting new ideas for how CP may integrate into diverse processes of cell physiology.

Original languageEnglish
Title of host publicationInternational Review of Cell and Molecular Biology
EditorsKwang Jeon
Pages183-206
Number of pages24
DOIs
StatePublished - 2008

Publication series

NameInternational Review of Cell and Molecular Biology
Volume267
ISSN (Print)1937-6448

Keywords

  • Actin
  • Capping protein
  • Cell migration
  • Cell motility
  • Polymerization
  • Sarcomere

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