New insights into innate immune restriction of West Nile virus infection

Helen M. Lazear, Michael S. Diamond

Research output: Contribution to journalReview article

30 Scopus citations

Abstract

West Nile virus (WNV) is an encephalitic flavivirus that has provided a valuable experimental system for studying viral pathogenesis and immunity. Although in vitro approaches and mouse models of infection have identified pattern recognition receptor and interferon pathways that control WNV infection, our appreciation of specific antiviral effectors has been more limited. In this review, we highlight recent advances in our understanding of the host factors that restrict WNV infection in mammals and insects, especially those resulting from large-scale screening approaches.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalCurrent Opinion in Virology
Volume11
Issue number1
DOIs
StatePublished - Jan 1 2015

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