New insights into basophil heterogeneity

Landon K. Oetjen; Mario Noti; Brian S. Kim

doi:10.1007/s00281-016-0567-z

New insights into basophil heterogeneity

Landon K. Oetjen, Mario Noti, Brian S. Kim

Research output: Contribution to journal › Review article › peer-review

29 Scopus citations

Abstract

Basophils have become increasingly recognized as important innate immune cells that mediate antihelminth immunity and barrier inflammation. Recent discoveries have uncovered previously unrecognized heterogeneity in basophil populations. However, how diversity in basophil regulation and function impacts human disease remains poorly defined. The goal of the present review is to highlight how new insights into basophil heterogeneity can help us to better understand disease pathogenesis and inform the development of new therapeutics.

Original language	English
Pages (from-to)	549-561
Number of pages	13
Journal	Seminars in Immunopathology
Volume	38
Issue number	5
DOIs	https://doi.org/10.1007/s00281-016-0567-z
State	Published - Sep 1 2016

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title = "New insights into basophil heterogeneity",

abstract = "Basophils have become increasingly recognized as important innate immune cells that mediate antihelminth immunity and barrier inflammation. Recent discoveries have uncovered previously unrecognized heterogeneity in basophil populations. However, how diversity in basophil regulation and function impacts human disease remains poorly defined. The goal of the present review is to highlight how new insights into basophil heterogeneity can help us to better understand disease pathogenesis and inform the development of new therapeutics.",

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AB - Basophils have become increasingly recognized as important innate immune cells that mediate antihelminth immunity and barrier inflammation. Recent discoveries have uncovered previously unrecognized heterogeneity in basophil populations. However, how diversity in basophil regulation and function impacts human disease remains poorly defined. The goal of the present review is to highlight how new insights into basophil heterogeneity can help us to better understand disease pathogenesis and inform the development of new therapeutics.

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U2 - 10.1007/s00281-016-0567-z

DO - 10.1007/s00281-016-0567-z

M3 - Review article

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EP - 561

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New insights into basophil heterogeneity

Abstract

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