New insights into basophil heterogeneity

Landon K. Oetjen, Mario Noti, Brian S. Kim

Research output: Contribution to journalReview articlepeer-review

22 Scopus citations

Abstract

Basophils have become increasingly recognized as important innate immune cells that mediate antihelminth immunity and barrier inflammation. Recent discoveries have uncovered previously unrecognized heterogeneity in basophil populations. However, how diversity in basophil regulation and function impacts human disease remains poorly defined. The goal of the present review is to highlight how new insights into basophil heterogeneity can help us to better understand disease pathogenesis and inform the development of new therapeutics.

Original languageEnglish
Pages (from-to)549-561
Number of pages13
JournalSeminars in Immunopathology
Volume38
Issue number5
DOIs
StatePublished - Sep 1 2016

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