New Horizons in Hyperpolarized 13C MRI

Myriam M. Chaumeil, James A. Bankson, Kevin M. Brindle, Shdema Epstein, Ferdia A. Gallagher, Martin Grashei, Caroline Guglielmetti, Joshua D. Kaggie, Kayvan R. Keshari, Stephan Knecht, Christoffer Laustsen, Andreas B. Schmidt, Daniel Vigneron, Yi Fen Yen, Franz Schilling

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Hyperpolarization techniques significantly enhance the sensitivity of magnetic resonance (MR) and thus present fascinating new directions for research and applications with in vivo MR imaging and spectroscopy (MRI/S). Hyperpolarized 13C MRI/S, in particular, enables real-time non-invasive assessment of metabolic processes and holds great promise for a diverse range of clinical applications spanning fields like oncology, neurology, and cardiology, with a potential for improving early diagnosis of disease, patient stratification, and therapy response assessment. Despite its potential, technical challenges remain for achieving clinical translation. This paper provides an overview of the discussions that took place at the international workshop “New Horizons in Hyperpolarized 13C MRI,” in March 2023 at the Bavarian Academy of Sciences and Humanities, Munich, Germany. The workshop covered new developments, as well as future directions, in topics including polarization techniques (particularly focusing on parahydrogen-based methods), novel probes, considerations related to data acquisition and analysis, and emerging clinical applications in oncology and other fields.

Original languageEnglish
Pages (from-to)222-232
Number of pages11
JournalMolecular Imaging and Biology
Issue number2
StatePublished - Apr 2024


  • Consensus
  • Hyperpolarized 13C
  • MR spectroscopy
  • MRI
  • Metabolic imaging
  • Metabolism


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