New developments in sleep research: Molecular genetics, gene expression, and systems neurobiology

Thomas S. Kilduff, Ed S. Lein, Horacio De La Iglesia, Takeshi Sakurai, Ying Hui Fu, Paul Shaw

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Understanding the mechanisms that underlie the control of sleep and wakefulness is a major research area in neuroscience. This mini-symposium review highlights some recent developments at the gene, molecular, cellular, and systems levels that have advanced this field. The studies discussed below use organisms ranging from flies tohumansand focus on the interaction between the sleep homeostatic and circadian systems, the consequences of mutations in genes involved in the circadian clock on sleep timing, the effects of sleep deprivation on brain gene expression, the discovery of "sleep active" neurons in the cerebral cortex, the role of the hypocretin/orexin system in the maintenance of sleep and wakefulness, and the interaction between sleep and learning.

Original languageEnglish
Pages (from-to)11814-11818
Number of pages5
JournalJournal of Neuroscience
Volume28
Issue number46
DOIs
StatePublished - Nov 12 2008

Keywords

  • Circadian system
  • Homeostatic system
  • Hypocretin/orexin system
  • Sleep and learning
  • Sleep deprivation
  • Sleep timing

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