Abstract
Advances in understanding the neurobiologic bases of anxiety are reviewed. The discovery of a class of compounds generically known as 'benzodiazepine antagonists' has been central to much of this work. One such group of compounds, the beta-carbolines, cause convulsions, produce an anxiety-like syndrome in primates, and reduce sleep. These compounds will provide a valuable means of investigating the mechanism of action of potential anxiolytics and of drugs currently used to treat anxious patients.
| Original language | English |
|---|---|
| Pages (from-to) | 12-20 |
| Number of pages | 9 |
| Journal | Journal of Clinical Psychiatry |
| Volume | 44 |
| Issue number | 11 II |
| State | Published - Dec 1 1983 |