New concepts in the neurobiology of anxiety

P. Skolnick, S. M. Paul

Research output: Contribution to journalArticlepeer-review

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Advances in understanding the neurobiologic bases of anxiety are reviewed. The discovery of a class of compounds generically known as 'benzodiazepine antagonists' has been central to much of this work. One such group of compounds, the beta-carbolines, cause convulsions, produce an anxiety-like syndrome in primates, and reduce sleep. These compounds will provide a valuable means of investigating the mechanism of action of potential anxiolytics and of drugs currently used to treat anxious patients.

Original languageEnglish
Pages (from-to)12-20
Number of pages9
JournalJournal of Clinical Psychiatry
Issue number11 II
StatePublished - Dec 1 1983


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