TY - JOUR
T1 - New Concepts in Steroid Glaucoma
AU - Levin, A. M.
AU - Sieck, E. G.
N1 - Publisher Copyright:
© 2023, The Author(s).
PY - 2023/12
Y1 - 2023/12
N2 - Purpose of Review: In this article, we discuss the pathophysiology underlying intraocular pressure elevation associated with corticosteroid use as well as targeted therapies for treatment. Recent Findings: Several signaling pathways at the level of the trabecular meshwork are altered by steroid exposure. A pre-existing diagnosis of glaucoma is the best-established risk factor for development of steroid-associated ocular hypertension. Topical, local, and systemic steroids have all been associated with ocular hypertension. Summary: Current management is directed at steroid-sparing alternatives to treatment, steroid cessation, IOP-lowering medications, and interventional lasers and surgery.
AB - Purpose of Review: In this article, we discuss the pathophysiology underlying intraocular pressure elevation associated with corticosteroid use as well as targeted therapies for treatment. Recent Findings: Several signaling pathways at the level of the trabecular meshwork are altered by steroid exposure. A pre-existing diagnosis of glaucoma is the best-established risk factor for development of steroid-associated ocular hypertension. Topical, local, and systemic steroids have all been associated with ocular hypertension. Summary: Current management is directed at steroid-sparing alternatives to treatment, steroid cessation, IOP-lowering medications, and interventional lasers and surgery.
KW - Corticosteroids
KW - Intraocular pressure
KW - Secondary open-angle glaucoma
KW - Steroid-induced glaucoma
KW - Trabecular meshwork
KW - Uveitis
UR - http://www.scopus.com/inward/record.url?scp=85168622971&partnerID=8YFLogxK
U2 - 10.1007/s40135-023-00316-9
DO - 10.1007/s40135-023-00316-9
M3 - Review article
AN - SCOPUS:85168622971
SN - 2167-4868
VL - 11
SP - 78
EP - 82
JO - Current Ophthalmology Reports
JF - Current Ophthalmology Reports
IS - 4
ER -