New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders

Evangelos Evangelou; He Gao; Congying Chu; Georgios Ntritsos; Paul Blakeley; Andrew R. Butts; Raha Pazoki; Hideaki Suzuki; Fotios Koskeridis; Andrianos M. Yiorkas; Ibrahim Karaman; Joshua Elliott; Qiang Luo; Stefanie Aeschbacher; Traci M. Bartz; Sebastian E. Baumeister; Peter S. Braund; Michael R. Brown; Jennifer A. Brody; Toni Kim Clarke; Niki Dimou; Jessica D. Faul; Georg Homuth; Anne U. Jackson; Katherine A. Kentistou; Peter K. Joshi; Rozenn N. Lemaitre; Penelope A. Lind; Leo Pekka Lyytikäinen; Massimo Mangino; Yuri Milaneschi; Christopher P. Nelson; Ilja M. Nolte; Mia Maria Perälä; Ozren Polasek; David Porteous; Scott M. Ratliff; Jennifer A. Smith; Alena Stančáková; Alexander Teumer; Samuli Tuominen; Sébastien Thériault; Jagadish Vangipurapu; John B. Whitfield; Alexis Wood; Jie Yao; Bing Yu; Wei Zhao; Dan E. Arking; Juha Auvinen; Chunyu Liu; Minna Männikkö; Lorenz Risch; Jerome I. Rotter; Harold Snieder; Juha Veijola; Alexandra I. Blakemore; Michael Boehnke; Harry Campbell; David Conen; Johan G. Eriksson; Hans J. Grabe; Xiuqing Guo; Pim van der Harst; Catharina A. Hartman; Caroline Hayward; Andrew C. Heath; Marjo Riitta Jarvelin; Mika Kähönen; Sharon L.R. Kardia; Michael Kühne; Johanna Kuusisto; Markku Laakso; Jari Lahti; Terho Lehtimäki; Andrew M. McIntosh; Karen L. Mohlke; Alanna C. Morrison; Nicholas G. Martin; Albertine J. Oldehinkel; Brenda W.J.H. Penninx; Bruce M. Psaty; Olli T. Raitakari; Igor Rudan; Nilesh J. Samani; Laura J. Scott; Tim D. Spector; Niek Verweij; David R. Weir; James F. Wilson; Daniel Levy; Ioanna Tzoulaki; Jimmy D. Bell; Paul M. Matthews; Adrian Rothenfluh; Sylvane Desrivières; Gunter Schumann; Paul Elliott

doi:10.1038/s41562-019-0653-z

New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders

Evangelos Evangelou, He Gao, Congying Chu, Georgios Ntritsos, Paul Blakeley, Andrew R. Butts, Raha Pazoki, Hideaki Suzuki, Fotios Koskeridis, Andrianos M. Yiorkas, Ibrahim Karaman, Joshua Elliott, Qiang Luo, Stefanie Aeschbacher, Traci M. Bartz, Sebastian E. Baumeister, Peter S. Braund, Michael R. Brown, Jennifer A. Brody, Toni Kim ClarkeNiki Dimou, Jessica D. Faul, Georg Homuth, Anne U. Jackson, Katherine A. Kentistou, Peter K. Joshi, Rozenn N. Lemaitre, Penelope A. Lind, Leo Pekka Lyytikäinen, Massimo Mangino, Yuri Milaneschi, Christopher P. Nelson, Ilja M. Nolte, Mia Maria Perälä, Ozren Polasek, David Porteous, Scott M. Ratliff, Jennifer A. Smith, Alena Stančáková, Alexander Teumer, Samuli Tuominen, Sébastien Thériault, Jagadish Vangipurapu, John B. Whitfield, Alexis Wood, Jie Yao, Bing Yu, Wei Zhao, Dan E. Arking, Juha Auvinen, Chunyu Liu, Minna Männikkö, Lorenz Risch, Jerome I. Rotter, Harold Snieder, Juha Veijola, Alexandra I. Blakemore, Michael Boehnke, Harry Campbell, David Conen, Johan G. Eriksson, Hans J. Grabe, Xiuqing Guo, Pim van der Harst, Catharina A. Hartman, Caroline Hayward, Andrew C. Heath, Marjo Riitta Jarvelin, Mika Kähönen, Sharon L.R. Kardia, Michael Kühne, Johanna Kuusisto, Markku Laakso, Jari Lahti, Terho Lehtimäki, Andrew M. McIntosh, Karen L. Mohlke, Alanna C. Morrison, Nicholas G. Martin, Albertine J. Oldehinkel, Brenda W.J.H. Penninx, Bruce M. Psaty, Olli T. Raitakari, Igor Rudan, Nilesh J. Samani, Laura J. Scott, Tim D. Spector, Niek Verweij, David R. Weir, James F. Wilson, Daniel Levy, Ioanna Tzoulaki, Jimmy D. Bell, Paul M. Matthews, Adrian Rothenfluh, Sylvane Desrivières, Gunter Schumann, Paul Elliott

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

Excessive alcohol consumption is one of the main causes of death and disability worldwide. Alcohol consumption is a heritable complex trait. Here we conducted a meta-analysis of genome-wide association studies of alcohol consumption (g d⁻¹) from the UK Biobank, the Alcohol Genome-Wide Consortium and the Cohorts for Heart and Aging Research in Genomic Epidemiology Plus consortia, collecting data from 480,842 people of European descent to decipher the genetic architecture of alcohol intake. We identified 46 new common loci and investigated their potential functional importance using magnetic resonance imaging data and gene expression studies. We identify genetic pathways associated with alcohol consumption and suggest genetic mechanisms that are shared with neuropsychiatric disorders such as schizophrenia.

Original language	English
Pages (from-to)	950-961
Number of pages	12
Journal	Nature Human Behaviour
Volume	3
Issue number	9
DOIs	https://doi.org/10.1038/s41562-019-0653-z
State	Published - Sep 1 2019

Access to Document

10.1038/s41562-019-0653-z

Cite this

Evangelou, E., Gao, H., Chu, C., Ntritsos, G., Blakeley, P., Butts, A. R., Pazoki, R., Suzuki, H., Koskeridis, F., Yiorkas, A. M., Karaman, I., Elliott, J., Luo, Q., Aeschbacher, S., Bartz, T. M., Baumeister, S. E., Braund, P. S., Brown, M. R., Brody, J. A., ... Elliott, P. (2019). New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders. Nature Human Behaviour, 3(9), 950-961. https://doi.org/10.1038/s41562-019-0653-z

@article{8d0cf2be42e644a1b535177e6a51f9b3,

title = "New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders",

abstract = "Excessive alcohol consumption is one of the main causes of death and disability worldwide. Alcohol consumption is a heritable complex trait. Here we conducted a meta-analysis of genome-wide association studies of alcohol consumption (g d−1) from the UK Biobank, the Alcohol Genome-Wide Consortium and the Cohorts for Heart and Aging Research in Genomic Epidemiology Plus consortia, collecting data from 480,842 people of European descent to decipher the genetic architecture of alcohol intake. We identified 46 new common loci and investigated their potential functional importance using magnetic resonance imaging data and gene expression studies. We identify genetic pathways associated with alcohol consumption and suggest genetic mechanisms that are shared with neuropsychiatric disorders such as schizophrenia.",

author = "Evangelos Evangelou and He Gao and Congying Chu and Georgios Ntritsos and Paul Blakeley and Butts, {Andrew R.} and Raha Pazoki and Hideaki Suzuki and Fotios Koskeridis and Yiorkas, {Andrianos M.} and Ibrahim Karaman and Joshua Elliott and Qiang Luo and Stefanie Aeschbacher and Bartz, {Traci M.} and Baumeister, {Sebastian E.} and Braund, {Peter S.} and Brown, {Michael R.} and Brody, {Jennifer A.} and Clarke, {Toni Kim} and Niki Dimou and Faul, {Jessica D.} and Georg Homuth and Jackson, {Anne U.} and Kentistou, {Katherine A.} and Joshi, {Peter K.} and Lemaitre, {Rozenn N.} and Lind, {Penelope A.} and Lyytik{\"a}inen, {Leo Pekka} and Massimo Mangino and Yuri Milaneschi and Nelson, {Christopher P.} and Nolte, {Ilja M.} and Per{\"a}l{\"a}, {Mia Maria} and Ozren Polasek and David Porteous and Ratliff, {Scott M.} and Smith, {Jennifer A.} and Alena Stan{\v c}{\'a}kov{\'a} and Alexander Teumer and Samuli Tuominen and S{\'e}bastien Th{\'e}riault and Jagadish Vangipurapu and Whitfield, {John B.} and Alexis Wood and Jie Yao and Bing Yu and Wei Zhao and Arking, {Dan E.} and Juha Auvinen and Chunyu Liu and Minna M{\"a}nnikk{\"o} and Lorenz Risch and Rotter, {Jerome I.} and Harold Snieder and Juha Veijola and Blakemore, {Alexandra I.} and Michael Boehnke and Harry Campbell and David Conen and Eriksson, {Johan G.} and Grabe, {Hans J.} and Xiuqing Guo and {van der Harst}, Pim and Hartman, {Catharina A.} and Caroline Hayward and Heath, {Andrew C.} and Jarvelin, {Marjo Riitta} and Mika K{\"a}h{\"o}nen and Kardia, {Sharon L.R.} and Michael K{\"u}hne and Johanna Kuusisto and Markku Laakso and Jari Lahti and Terho Lehtim{\"a}ki and McIntosh, {Andrew M.} and Mohlke, {Karen L.} and Morrison, {Alanna C.} and Martin, {Nicholas G.} and Oldehinkel, {Albertine J.} and Penninx, {Brenda W.J.H.} and Psaty, {Bruce M.} and Raitakari, {Olli T.} and Igor Rudan and Samani, {Nilesh J.} and Scott, {Laura J.} and Spector, {Tim D.} and Niek Verweij and Weir, {David R.} and Wilson, {James F.} and Daniel Levy and Ioanna Tzoulaki and Bell, {Jimmy D.} and Matthews, {Paul M.} and Adrian Rothenfluh and Sylvane Desrivi{\`e}res and Gunter Schumann and Paul Elliott",

note = "Funding Information: H.G. was funded by the NIHR Imperial College Health Care NHS Trust and Imperial College London Biomedical Research Centre. I.K. was supported by the EU PhenoMeNal project (Horizon 2020, grant no. 654241) and the UK Dementia Research Institute, which is supported by the MRC, the Alzheimer{\textquoteright}s Society and Alzheimer{\textquoteright}s Research UK. S. Th{\'e}riault was supported by the Canadian Institutes of Health Research and Universit{\'e} Laval (Quebec City, Canada). L.R. was supported by Forschungs-und F{\"o}rder-Stiftung INOVA, Vaduz, Liechtenstein. D.C. holds a McMaster University Department of Medicine Mid-Career Research Award. M.B. is supported by NIH grant R01-DK062370. P.v.d.H. was supported by ICIN-NHI and Marie Sk{\l}odowska-Curie GF (call: H2020-MSCA-IF-2014; Project ID: 661395). C.H. was supported by a core MRC grant to the MRCHGU QTL in Health and Disease research programme. N.V. was supported by Marie Sk{\l}odowska-Curie GF (grant no. 661395) and ICIN-NHI. Q.L. is partially supported by the National Natural Sciences Foundation of China (No. 81873909), Shanghai Municipal Science and Technology Major Project(No.2018SHZDZX01) and ZJLab. P.E. acknowledges support from the NIHR Biomedical Research Centre at Imperial College Healthcare NHS Trust and Imperial College London, the NIHR Health Protection Research Unit in Health Impact of Environmental Hazards (HPRU-2012-10141), the Medical Research Council (MRC) and Public Health England (PHE) Centre for Environment and Health (MR/L01341X/1) and Health Data Research (HDR) UK. P.E. is supported by a UK Dementia Research Institute (DRI) professorship, UK DRI at Imperial College London, funded by the MRC, Alzheimer{\textquoteright}s Society and Alzheimer{\textquoteright}s Research UK. This work received support from the following sources: the European Union-funded FP6 Integrated Project IMAGEN (Reinforcement-related behaviour in normal brain function and psychopathology; LSHM-CT-2007-037286), the Horizon 2020 funded ERC Advanced Grant {\textquoteleft}STRATIFY{\textquoteright} (Brain network based stratification of reinforcement-related disorders; grant no. 695313), ERANID (Understanding the interplay between cultural, biological and subjective factors in drug use pathways; PR-ST-0416-10004), BRIDGET (JPND: BRain Imaging, cognition Dementia and next generation GEnomics; MR/N027558/1), the FP7 projects IMAGEMEND (grant no. 602450; IMAging GEnetics for MENtal Disorders) and MATRICS (grant no. 603016), the Innovative Medicine Initiative Project EU-AIMS (grant. no115300-2), the Medical Research Council Grant {\textquoteleft}c-VEDA{\textquoteright} (Consortium on Vulnerability to Externalizing Disorders and Addictions; MR/N000390/1), the Swedish Research Council FORMAS, the Medical Research Council, the National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King{\textquoteright}s College London, the Bundesministeriumf{\"u}r Bildung und Forschung (BMBF grants 01GS08152; 01EV0711; eMED SysAlc01ZX1311A; and Forschungsnetz AERIAL 01EE1406A and 01EE1406B), the Deutsche Forschungsgemeinschaft (DFG grants SM 80/7-2 and SFB 940/2), the Medical Research Foundation and Medical Research Council (MR/R00465X/1), the Human Brain Project (HBP SGA 2). Further support was provided by grants from ANR (project AF12-NEUR0008-01-WM2NA, and ANR-12-SAMA-0004), the Fondation de France, the Fondation pour la Recherche M{\'e}dicale, the Mission Interminist{\'e}rielle de Lutte-contre-les-Drogues-et-les-Conduites-Addictives (MILDECA), the Assistance-Publique-H{\^o}pitaux-de-Paris and INSERM (interface grant), Paris Sud University IDEX 2012; the National Institutes of Health, Science Foundation Ireland (16/ERCD/3797), USA (Axon, Testosterone and Mental Health during Adolescence; RO1 MH085772-01A1); and by NIH Consortium grant U54 EB020403, supported by a cross-NIH alliance that funds Big Data to Knowledge Centres of Excellence. The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript. Publisher Copyright: {\textcopyright} 2019, The Author(s), under exclusive licence to Springer Nature Limited.",

year = "2019",

month = sep,

day = "1",

doi = "10.1038/s41562-019-0653-z",

language = "English",

volume = "3",

pages = "950--961",

journal = "Nature Human Behaviour",

issn = "2397-3374",

number = "9",

}

Evangelou, E, Gao, H, Chu, C, Ntritsos, G, Blakeley, P, Butts, AR, Pazoki, R, Suzuki, H, Koskeridis, F, Yiorkas, AM, Karaman, I, Elliott, J, Luo, Q, Aeschbacher, S, Bartz, TM, Baumeister, SE, Braund, PS, Brown, MR, Brody, JA, Clarke, TK, Dimou, N, Faul, JD, Homuth, G, Jackson, AU, Kentistou, KA, Joshi, PK, Lemaitre, RN, Lind, PA, Lyytikäinen, LP, Mangino, M, Milaneschi, Y, Nelson, CP, Nolte, IM, Perälä, MM, Polasek, O, Porteous, D, Ratliff, SM, Smith, JA, Stančáková, A, Teumer, A, Tuominen, S, Thériault, S, Vangipurapu, J, Whitfield, JB, Wood, A, Yao, J, Yu, B, Zhao, W, Arking, DE, Auvinen, J, Liu, C, Männikkö, M, Risch, L, Rotter, JI, Snieder, H, Veijola, J, Blakemore, AI, Boehnke, M, Campbell, H, Conen, D, Eriksson, JG, Grabe, HJ, Guo, X, van der Harst, P, Hartman, CA, Hayward, C, Heath, AC, Jarvelin, MR, Kähönen, M, Kardia, SLR, Kühne, M, Kuusisto, J, Laakso, M, Lahti, J, Lehtimäki, T, McIntosh, AM, Mohlke, KL, Morrison, AC, Martin, NG, Oldehinkel, AJ, Penninx, BWJH, Psaty, BM, Raitakari, OT, Rudan, I, Samani, NJ, Scott, LJ, Spector, TD, Verweij, N, Weir, DR, Wilson, JF, Levy, D, Tzoulaki, I, Bell, JD, Matthews, PM, Rothenfluh, A, Desrivières, S, Schumann, G & Elliott, P 2019, 'New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders', Nature Human Behaviour, vol. 3, no. 9, pp. 950-961. https://doi.org/10.1038/s41562-019-0653-z

TY - JOUR

T1 - New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders

AU - Evangelou, Evangelos

AU - Gao, He

AU - Chu, Congying

AU - Ntritsos, Georgios

AU - Blakeley, Paul

AU - Butts, Andrew R.

AU - Pazoki, Raha

AU - Suzuki, Hideaki

AU - Koskeridis, Fotios

AU - Yiorkas, Andrianos M.

AU - Karaman, Ibrahim

AU - Elliott, Joshua

AU - Luo, Qiang

AU - Aeschbacher, Stefanie

AU - Bartz, Traci M.

AU - Baumeister, Sebastian E.

AU - Braund, Peter S.

AU - Brown, Michael R.

AU - Brody, Jennifer A.

AU - Clarke, Toni Kim

AU - Dimou, Niki

AU - Faul, Jessica D.

AU - Homuth, Georg

AU - Jackson, Anne U.

AU - Kentistou, Katherine A.

AU - Joshi, Peter K.

AU - Lemaitre, Rozenn N.

AU - Lind, Penelope A.

AU - Lyytikäinen, Leo Pekka

AU - Mangino, Massimo

AU - Milaneschi, Yuri

AU - Nelson, Christopher P.

AU - Nolte, Ilja M.

AU - Perälä, Mia Maria

AU - Polasek, Ozren

AU - Porteous, David

AU - Ratliff, Scott M.

AU - Smith, Jennifer A.

AU - Stančáková, Alena

AU - Teumer, Alexander

AU - Tuominen, Samuli

AU - Thériault, Sébastien

AU - Vangipurapu, Jagadish

AU - Whitfield, John B.

AU - Wood, Alexis

AU - Yao, Jie

AU - Yu, Bing

AU - Zhao, Wei

AU - Arking, Dan E.

AU - Auvinen, Juha

AU - Liu, Chunyu

AU - Männikkö, Minna

AU - Risch, Lorenz

AU - Rotter, Jerome I.

AU - Snieder, Harold

AU - Veijola, Juha

AU - Blakemore, Alexandra I.

AU - Boehnke, Michael

AU - Campbell, Harry

AU - Conen, David

AU - Eriksson, Johan G.

AU - Grabe, Hans J.

AU - Guo, Xiuqing

AU - van der Harst, Pim

AU - Hartman, Catharina A.

AU - Hayward, Caroline

AU - Heath, Andrew C.

AU - Jarvelin, Marjo Riitta

AU - Kähönen, Mika

AU - Kardia, Sharon L.R.

AU - Kühne, Michael

AU - Kuusisto, Johanna

AU - Laakso, Markku

AU - Lahti, Jari

AU - Lehtimäki, Terho

AU - McIntosh, Andrew M.

AU - Mohlke, Karen L.

AU - Morrison, Alanna C.

AU - Martin, Nicholas G.

AU - Oldehinkel, Albertine J.

AU - Penninx, Brenda W.J.H.

AU - Psaty, Bruce M.

AU - Raitakari, Olli T.

AU - Rudan, Igor

AU - Samani, Nilesh J.

AU - Scott, Laura J.

AU - Spector, Tim D.

AU - Verweij, Niek

AU - Weir, David R.

AU - Wilson, James F.

AU - Levy, Daniel

AU - Tzoulaki, Ioanna

AU - Bell, Jimmy D.

AU - Matthews, Paul M.

AU - Rothenfluh, Adrian

AU - Desrivières, Sylvane

AU - Schumann, Gunter

AU - Elliott, Paul

N1 - Funding Information: H.G. was funded by the NIHR Imperial College Health Care NHS Trust and Imperial College London Biomedical Research Centre. I.K. was supported by the EU PhenoMeNal project (Horizon 2020, grant no. 654241) and the UK Dementia Research Institute, which is supported by the MRC, the Alzheimer’s Society and Alzheimer’s Research UK. S. Thériault was supported by the Canadian Institutes of Health Research and Université Laval (Quebec City, Canada). L.R. was supported by Forschungs-und Förder-Stiftung INOVA, Vaduz, Liechtenstein. D.C. holds a McMaster University Department of Medicine Mid-Career Research Award. M.B. is supported by NIH grant R01-DK062370. P.v.d.H. was supported by ICIN-NHI and Marie Skłodowska-Curie GF (call: H2020-MSCA-IF-2014; Project ID: 661395). C.H. was supported by a core MRC grant to the MRCHGU QTL in Health and Disease research programme. N.V. was supported by Marie Skłodowska-Curie GF (grant no. 661395) and ICIN-NHI. Q.L. is partially supported by the National Natural Sciences Foundation of China (No. 81873909), Shanghai Municipal Science and Technology Major Project(No.2018SHZDZX01) and ZJLab. P.E. acknowledges support from the NIHR Biomedical Research Centre at Imperial College Healthcare NHS Trust and Imperial College London, the NIHR Health Protection Research Unit in Health Impact of Environmental Hazards (HPRU-2012-10141), the Medical Research Council (MRC) and Public Health England (PHE) Centre for Environment and Health (MR/L01341X/1) and Health Data Research (HDR) UK. P.E. is supported by a UK Dementia Research Institute (DRI) professorship, UK DRI at Imperial College London, funded by the MRC, Alzheimer’s Society and Alzheimer’s Research UK. This work received support from the following sources: the European Union-funded FP6 Integrated Project IMAGEN (Reinforcement-related behaviour in normal brain function and psychopathology; LSHM-CT-2007-037286), the Horizon 2020 funded ERC Advanced Grant ‘STRATIFY’ (Brain network based stratification of reinforcement-related disorders; grant no. 695313), ERANID (Understanding the interplay between cultural, biological and subjective factors in drug use pathways; PR-ST-0416-10004), BRIDGET (JPND: BRain Imaging, cognition Dementia and next generation GEnomics; MR/N027558/1), the FP7 projects IMAGEMEND (grant no. 602450; IMAging GEnetics for MENtal Disorders) and MATRICS (grant no. 603016), the Innovative Medicine Initiative Project EU-AIMS (grant. no115300-2), the Medical Research Council Grant ‘c-VEDA’ (Consortium on Vulnerability to Externalizing Disorders and Addictions; MR/N000390/1), the Swedish Research Council FORMAS, the Medical Research Council, the National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King’s College London, the Bundesministeriumfür Bildung und Forschung (BMBF grants 01GS08152; 01EV0711; eMED SysAlc01ZX1311A; and Forschungsnetz AERIAL 01EE1406A and 01EE1406B), the Deutsche Forschungsgemeinschaft (DFG grants SM 80/7-2 and SFB 940/2), the Medical Research Foundation and Medical Research Council (MR/R00465X/1), the Human Brain Project (HBP SGA 2). Further support was provided by grants from ANR (project AF12-NEUR0008-01-WM2NA, and ANR-12-SAMA-0004), the Fondation de France, the Fondation pour la Recherche Médicale, the Mission Interministérielle de Lutte-contre-les-Drogues-et-les-Conduites-Addictives (MILDECA), the Assistance-Publique-Hôpitaux-de-Paris and INSERM (interface grant), Paris Sud University IDEX 2012; the National Institutes of Health, Science Foundation Ireland (16/ERCD/3797), USA (Axon, Testosterone and Mental Health during Adolescence; RO1 MH085772-01A1); and by NIH Consortium grant U54 EB020403, supported by a cross-NIH alliance that funds Big Data to Knowledge Centres of Excellence. The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript. Publisher Copyright: © 2019, The Author(s), under exclusive licence to Springer Nature Limited.

PY - 2019/9/1

Y1 - 2019/9/1

N2 - Excessive alcohol consumption is one of the main causes of death and disability worldwide. Alcohol consumption is a heritable complex trait. Here we conducted a meta-analysis of genome-wide association studies of alcohol consumption (g d−1) from the UK Biobank, the Alcohol Genome-Wide Consortium and the Cohorts for Heart and Aging Research in Genomic Epidemiology Plus consortia, collecting data from 480,842 people of European descent to decipher the genetic architecture of alcohol intake. We identified 46 new common loci and investigated their potential functional importance using magnetic resonance imaging data and gene expression studies. We identify genetic pathways associated with alcohol consumption and suggest genetic mechanisms that are shared with neuropsychiatric disorders such as schizophrenia.

AB - Excessive alcohol consumption is one of the main causes of death and disability worldwide. Alcohol consumption is a heritable complex trait. Here we conducted a meta-analysis of genome-wide association studies of alcohol consumption (g d−1) from the UK Biobank, the Alcohol Genome-Wide Consortium and the Cohorts for Heart and Aging Research in Genomic Epidemiology Plus consortia, collecting data from 480,842 people of European descent to decipher the genetic architecture of alcohol intake. We identified 46 new common loci and investigated their potential functional importance using magnetic resonance imaging data and gene expression studies. We identify genetic pathways associated with alcohol consumption and suggest genetic mechanisms that are shared with neuropsychiatric disorders such as schizophrenia.

UR - http://www.scopus.com/inward/record.url?scp=85070108168&partnerID=8YFLogxK

U2 - 10.1038/s41562-019-0653-z

DO - 10.1038/s41562-019-0653-z

M3 - Article

C2 - 31358974

AN - SCOPUS:85070108168

SN - 2397-3374

VL - 3

SP - 950

EP - 961

JO - Nature Human Behaviour

JF - Nature Human Behaviour

IS - 9

ER -

New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders

Abstract

Access to Document

Other files and links

Fingerprint

Cite this