New acetylenic metabolites from the marine sponge Pellina triangulata

Fu Xiong, Syed A. Abbas, Francis J. Schmitz, Ilan Vidavsky, Michael L. Gross, Maureen Laney, Randall C. Schatzman, Ronnel D. Cabuslay

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


Six new acetylenic compounds, 1, 7-11, were isolated from the marine sponge Pellina triangulata. Structures were established using NMR spectroscopy and chemical degradation. Collisional activation decomposition (CAD) tandem mass spectrometry of the lithium adducts of the acetylenic compounds was applied to ascertain if charge-remote fragmentation would yield definitive information regarding the site of internal unsaturation in these polyfunctional compounds. Pellynic acid (1) inhibited inosine monophosphate dehydrogenase (IMPDH) in vitro.

Original languageEnglish
Pages (from-to)799-814
Number of pages16
Issue number3
StatePublished - Jan 20 1997


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