@article{e28cbc54843c45fd9877fe1313137be3,
title = "New acetylenic metabolites from the marine sponge Pellina triangulata",
abstract = "Six new acetylenic compounds, 1, 7-11, were isolated from the marine sponge Pellina triangulata. Structures were established using NMR spectroscopy and chemical degradation. Collisional activation decomposition (CAD) tandem mass spectrometry of the lithium adducts of the acetylenic compounds was applied to ascertain if charge-remote fragmentation would yield definitive information regarding the site of internal unsaturation in these polyfunctional compounds. Pellynic acid (1) inhibited inosine monophosphate dehydrogenase (IMPDH) in vitro.",
author = "Fu Xiong and Abbas, {Syed A.} and Schmitz, {Francis J.} and Ilan Vidavsky and Gross, {Michael L.} and Maureen Laney and Schatzman, {Randall C.} and Cabuslay, {Ronnel D.}",
note = "Funding Information: This work was supported by NIH grant CA 52955. FJS thanks Dr. M. Kelly-Borges for sponge identification, the Coral Reef Research Foundation for use of its facilities and the Government of Chuuk, Federated States of Micronesia for permission to collect specimens. We gratefully acknowledge NSF Grant CHE 8113507 and the University of Oklahoma Research Associates Fund for funds to purchase a high-field NMR spectrometer, and NM grant 2P41PROO954 to Washington University for support of the mass spectrometry research resource.",
year = "1997",
month = jan,
day = "20",
doi = "10.1016/S0040-4020(96)01037-X",
language = "English",
volume = "53",
pages = "799--814",
journal = "Tetrahedron",
issn = "0040-4020",
number = "3",
}