New 2-[(5-methoxy-1-methylindolyl)]-alkylamine derivatives: The effect of branching and elongation of the side chain on MAO inhibition

J. A. Morón; V. Perez; J. L. Marco; E. Fernandez-Alvarez; M. Unzeta

doi:10.3109/14756369809021473

New 2-[(5-methoxy-1-methylindolyl)]-alkylamine derivatives: The effect of branching and elongation of the side chain on MAO inhibition

J. A. Morón
, V. Perez
, J. L. Marco
, E. Fernandez-Alvarez
, M. Unzeta

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

A novel series of previously synthesised 2-[(5-methoxy-1-methylindolyl)]alkylamine derivatives were irreversible and time-dependent mechanism-based inhibitors of MAO. The effect of branching and elongation of the side chain was evaluated on the inhibitory potency towards MAO-A and MAO-B activities. The K(I) of the reversible step and the k(inact) of the irreversible one were determined in each case. The results obtained lead to the conclusion that neither the elongation nor the branching of the side chain improve the potency of the compounds as MAO inhibitors.

Original language	English
Pages (from-to)	237-251
Number of pages	15
Journal	Journal of Enzyme Inhibition
Volume	13
Issue number	4
DOIs	https://doi.org/10.3109/14756369809021473
State	Published - 1998

Keywords

Indolalkylamine derivatives
Inhibition
Kinetics
Monoamine oxidase

Access to Document

10.3109/14756369809021473

Cite this

@article{d9ddc1a154d4478aa23b6e5f856c5b45,

title = "New 2-[(5-methoxy-1-methylindolyl)]-alkylamine derivatives: The effect of branching and elongation of the side chain on MAO inhibition",

abstract = "A novel series of previously synthesised 2-[(5-methoxy-1-methylindolyl)]alkylamine derivatives were irreversible and time-dependent mechanism-based inhibitors of MAO. The effect of branching and elongation of the side chain was evaluated on the inhibitory potency towards MAO-A and MAO-B activities. The K(I) of the reversible step and the k(inact) of the irreversible one were determined in each case. The results obtained lead to the conclusion that neither the elongation nor the branching of the side chain improve the potency of the compounds as MAO inhibitors.",

keywords = "Indolalkylamine derivatives, Inhibition, Kinetics, Monoamine oxidase",

author = "Mor{\'o}n, \{J. A.\} and V. Perez and Marco, \{J. L.\} and E. Fernandez-Alvarez and M. Unzeta",

note = "Funding Information: This work has been supported in part by the DGR grant QFN 93-4428 from the Comissionat per a Universitats i Recerca of Generalitat de Catalunya.",

year = "1998",

doi = "10.3109/14756369809021473",

language = "English",

volume = "13",

pages = "237--251",

journal = "Journal of Enzyme Inhibition",

issn = "8755-5093",

number = "4",

}

TY - JOUR

T1 - New 2-[(5-methoxy-1-methylindolyl)]-alkylamine derivatives

T2 - The effect of branching and elongation of the side chain on MAO inhibition

AU - Morón, J. A.

AU - Perez, V.

AU - Marco, J. L.

AU - Fernandez-Alvarez, E.

AU - Unzeta, M.

N1 - Funding Information: This work has been supported in part by the DGR grant QFN 93-4428 from the Comissionat per a Universitats i Recerca of Generalitat de Catalunya.

PY - 1998

Y1 - 1998

N2 - A novel series of previously synthesised 2-[(5-methoxy-1-methylindolyl)]alkylamine derivatives were irreversible and time-dependent mechanism-based inhibitors of MAO. The effect of branching and elongation of the side chain was evaluated on the inhibitory potency towards MAO-A and MAO-B activities. The K(I) of the reversible step and the k(inact) of the irreversible one were determined in each case. The results obtained lead to the conclusion that neither the elongation nor the branching of the side chain improve the potency of the compounds as MAO inhibitors.

AB - A novel series of previously synthesised 2-[(5-methoxy-1-methylindolyl)]alkylamine derivatives were irreversible and time-dependent mechanism-based inhibitors of MAO. The effect of branching and elongation of the side chain was evaluated on the inhibitory potency towards MAO-A and MAO-B activities. The K(I) of the reversible step and the k(inact) of the irreversible one were determined in each case. The results obtained lead to the conclusion that neither the elongation nor the branching of the side chain improve the potency of the compounds as MAO inhibitors.

KW - Indolalkylamine derivatives

KW - Inhibition

KW - Kinetics

KW - Monoamine oxidase

UR - https://www.scopus.com/pages/publications/0031694791

U2 - 10.3109/14756369809021473

DO - 10.3109/14756369809021473

M3 - Article

C2 - 9795863

AN - SCOPUS:0031694791

SN - 8755-5093

VL - 13

SP - 237

EP - 251

JO - Journal of Enzyme Inhibition

JF - Journal of Enzyme Inhibition

IS - 4

ER -

New 2-[(5-methoxy-1-methylindolyl)]-alkylamine derivatives: The effect of branching and elongation of the side chain on MAO inhibition

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this