Neutrophil-derived serine proteases in immune complex-mediated diseases

Sofia Z. Raptis; Christine T.N. Pham

doi:10.1385/IR:32:1-3:211

Neutrophil-derived serine proteases in immune complex-mediated diseases

Sofia Z. Raptis, Christine T.N. Pham

Research output: Contribution to journal › Review article › peer-review

6 Scopus citations

Abstract

Neutrophil-derived serine proteases play an important role in fighting infections. However, emerging data suggest that these proteases also regulate noninfectious inflammatory responses. Loss-of-function mutations in serine proteases have provided critical insights into the significance of these serine proteases in initiating and amplifying immune complex-mediated diseases.

Original language	English
Pages (from-to)	211-215
Number of pages	5
Journal	Immunologic Research
Volume	32
Issue number	1-3
DOIs	https://doi.org/10.1385/IR:32:1-3:211
State	Published - 2005

Keywords

Cathepsin G
Inflammation
Neutrophil elastase
Neutrophils
Serine proteases

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10.1385/IR:32:1-3:211

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title = "Neutrophil-derived serine proteases in immune complex-mediated diseases",

abstract = "Neutrophil-derived serine proteases play an important role in fighting infections. However, emerging data suggest that these proteases also regulate noninfectious inflammatory responses. Loss-of-function mutations in serine proteases have provided critical insights into the significance of these serine proteases in initiating and amplifying immune complex-mediated diseases.",

keywords = "Cathepsin G, Inflammation, Neutrophil elastase, Neutrophils, Serine proteases",

author = "Raptis, {Sofia Z.} and Pham, {Christine T.N.}",

note = "Funding Information: This work was supported by grants from the Arthritis Foundation and National Institutes of Health (AI49261).",

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AU - Raptis, Sofia Z.

AU - Pham, Christine T.N.

N1 - Funding Information: This work was supported by grants from the Arthritis Foundation and National Institutes of Health (AI49261).

PY - 2005

Y1 - 2005

N2 - Neutrophil-derived serine proteases play an important role in fighting infections. However, emerging data suggest that these proteases also regulate noninfectious inflammatory responses. Loss-of-function mutations in serine proteases have provided critical insights into the significance of these serine proteases in initiating and amplifying immune complex-mediated diseases.

AB - Neutrophil-derived serine proteases play an important role in fighting infections. However, emerging data suggest that these proteases also regulate noninfectious inflammatory responses. Loss-of-function mutations in serine proteases have provided critical insights into the significance of these serine proteases in initiating and amplifying immune complex-mediated diseases.

KW - Cathepsin G

KW - Inflammation

KW - Neutrophil elastase

KW - Neutrophils

KW - Serine proteases

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U2 - 10.1385/IR:32:1-3:211

DO - 10.1385/IR:32:1-3:211

M3 - Review article

C2 - 16106072

AN - SCOPUS:23844528061

SN - 0257-277X

VL - 32

SP - 211

EP - 215

JO - Immunologic Research

JF - Immunologic Research

IS - 1-3

ER -

Neutrophil-derived serine proteases in immune complex-mediated diseases

Abstract

Keywords

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