Neutralizing Antibody Immune Correlates for a Recombinant Protein Vaccine in the COVAIL Trial

Coronavirus Variant Immunologic Landscape Trial (COVAIL) Study Team

doi:10.1093/cid/ciae465

Neutralizing Antibody Immune Correlates for a Recombinant Protein Vaccine in the COVAIL Trial

Coronavirus Variant Immunologic Landscape Trial (COVAIL) Study Team

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

For COVAIL recipients of a coronavirus disease 2019 (COVID-19) Sanofi booster vaccine, neutralizing antibody titers were assessed as a correlate of risk (CoR) of COVID-19. Peak and exposure-proximal titers were inverse CoRs with covariate-adjusted hazard ratios (95% confidence intervals) 0.30 (0.11, 0.78) and 0.25 (0.07, 0.85) per 10-fold increase in weighted average titer.

Original language	English
Pages (from-to)	223-227
Number of pages	5
Journal	Clinical Infectious Diseases
Volume	80
Issue number	1
DOIs	https://doi.org/10.1093/cid/ciae465
State	Published - Jan 15 2025

Keywords

COVID-19 booster
Omicron
correlate of risk
exposure-proximal titer
variant vaccine booster

Access to Document

10.1093/cid/ciae465

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@article{76996689232f451fb5e7d1b3b8758398,

title = "Neutralizing Antibody Immune Correlates for a Recombinant Protein Vaccine in the COVAIL Trial",

abstract = "For COVAIL recipients of a coronavirus disease 2019 (COVID-19) Sanofi booster vaccine, neutralizing antibody titers were assessed as a correlate of risk (CoR) of COVID-19. Peak and exposure-proximal titers were inverse CoRs with covariate-adjusted hazard ratios (95\% confidence intervals) 0.30 (0.11, 0.78) and 0.25 (0.07, 0.85) per 10-fold increase in weighted average titer.",

keywords = "COVID-19 booster, Omicron, correlate of risk, exposure-proximal titer, variant vaccine booster",

author = "\{Coronavirus Variant Immunologic Landscape Trial (COVAIL) Study Team\} and Youyi Fong and Lauren Dang and Bo Zhang and Jonathan Fintzi and Shiyu Chen and Jing Wang and Rouphael, \{Nadine G.\} and Branche, \{Angela R.\} and Diemert, \{David J.\} and Falsey, \{Ann R.\} and Cecilia Losada and Baden, \{Lindsey R.\} and Frey, \{Sharon E.\} and Whitaker, \{Jennifer A.\} and Little, \{Susan J.\} and Satoshi Kamidani and Walter, \{Emmanuel B.\} and Novak, \{Richard M.\} and Richard Rupp and Jackson, \{Lisa A.\} and Chenchen Yu and Magaret, \{Craig A.\} and Cindy Molitor and Bhavesh Borate and Babu, \{Tara M.\} and Kottkamp, \{Angelica C.\} and Luetkemeyer, \{Anne F.\} and Immergluck, \{Lilly C.\} and Presti, \{Rachel M.\} and Mart{\'i}n B{\"a}cker and Winokur, \{Patricia L.\} and Mahgoub, \{Siham M.\} and Goepfert, \{Paul A.\} and Fusco, \{Dahlene N.\} and Atmar, \{Robert L.\} and Posavad, \{Christine M.\} and Jinjian Mu and Mat Makowski and Makhene, \{Mamodikoe K.\} and Nayak, \{Seema U.\} and Roberts, \{Paul C.\} and Dean Follmann and Gilbert, \{Peter B.\} and Elissa Malkin and Bethony, \{Jeffrey M.\} and Aimee Desrosiers and Marc Siegel and Edward Walsh and Patrick Kingsley and Michael Peasley and Graciaa, \{Daniel S.\} and Hady Samaha and Rebolledo, \{Paulina A.\} and Zanthia Wiley and Sherman, \{Amy C.\} and Walsh, \{Stephen R.\} and Alexandra Tong and Rebecca Rooks and Getahun Abate and Zacharoula Oikonomopoulou and Hoft, \{Daniel F.\} and Irene Graham and \{El Sahly\}, \{Hana M.\} and Keitel, \{Wendy A.\} and \{Mary Healy\}, C. and \{Robert Atmar\}, L. and \{Susan Little\}, J. and \{Thomas Martin\}, \{C. S.\} and Nicole Carter and Steven Hendrickx and Anderson, \{Evan J.\} and \{Christina Rostad\}, A. and Etza Peters and Smith, \{Michael J.\} and \{Anthony Moody\}, M. and Schmader, \{Kenneth E.\} and Ladner, \{Benjamin G.\} and Andrea Wendrow and Jessica Herrick and Laura Porterfield and Maya Dunstan and Rebecca Lau and Barbara Carste and Anna Wald and Taylor Krause and Kirsten Hauge and Mulligan, \{Mark J.\} and Tamia Davis and Celia Engelson and Vijaya Soma and Chloe Harris and Lopez, \{Azquena Munoz\} and Erica Johnson and Austin Chan and O'Halloran, \{Jane A.\} and Thompson, \{Ryley M.\} and Fleming, \{Andrew B.\} and Asif Noor and Jeffery Meier and Jack Stapleton and Celia Maxwell and Sarah Shami and Drouin, \{Arnaud C.\} and Numbi, \{Florice K.\} and Lyke, \{Kirsten E.\} and Stephens, \{David S.\} and Neuzil, \{Kathleen M.\} and Farley, \{Monica M.\} and Jeanne Marrazzo and Young, \{Sidnee Paschal\} and Jeffery Lennox and Linda McNeil and Elizabeth Brown and Meagher, \{Megan A.\} and Julie McElrath and Mike Gale and Kuleni Abebe and Heather Hill and Jim Albert and Holly Baughman and Lisa McQuarrie and Kalyani Telu and McQuarrie, \{Lisa J.\} and Lewis, \{Teri C.\} and Giebeig, \{Lisa A.\} and Engel, \{Theresa M.\} and Griffith, \{Caleb J.\} and McDonald, \{Wendi L.\} and Burkey, \{Alissa E.\} and Hoopengardner, \{Lisa B.\} and Linton, \{Jessica E.\} and Gettinger, \{Nikki L.\} and Montefiori, \{David C.\} and Amanda Eaton and Smith, \{Derek J.\} and Antonia Netzl and Wilks, \{Samuel H.\} and Sina T{\"u}reli and Mamodikoe Makhene and Mohamed Elsafy and Rhonda Pikaart-Tautges and Janice Arega and Binh Hoang and Dan Curtin and Hyung Koo and Elisa Sindall and Sonja Crandon and Degrace, \{Marciela M.\} and Post, \{Diane J.\} and Beigel, \{John H.\} and Ackerley, \{Cassie Grimsley\} and Unterberger, \{Kristen E.\} and Amy Anderson and Mary Atha and Kareem Bechnak and Sarah Bechnak and Mary Bower and Laura Clegg and Matthew Collins and Francine Dyer and Srilatha Edupuganti and Rebecca Fineman and Tigisty Girmay and Rebecca Gonzalez and Natalie Gray and Evan Gutter and Lisa Harewood and Chris Huerta and Brandi Johnson and Lauren Johnson and Colleen Kelley and Alexandra Koumanelis and Deborah Laryea and Hollie MacEnczak and Nour Makkaoui and Michele McCullough and Ngo, \{Tuong Vy\} and Eileen Osinski and Julia Paine and Bernadine Panganiban and Rose Pope and Paulina Rebolledo and Susan Rogers and Erin Scherer and Veronica Smith and Andre Stringer and Jessica Traenkner and Dongli Wang and Alahna Watson and Stacey Wheeler and Jean Winter and Jianguo Xu and Kleinjan, \{Jane A.\} and Gothing, \{Jon A.\} and \{Avila Paz\}, \{Andres A.\} and Aleissa, \{Muneerah M.\} and Bethany Evans and August Heithoff and Izaguirre, \{Natalie E.\} and Michael Klebert",

year = "2025",

month = jan,

day = "15",

doi = "10.1093/cid/ciae465",

language = "English",

volume = "80",

pages = "223--227",

journal = "Clinical Infectious Diseases",

issn = "1058-4838",

number = "1",

}

TY - JOUR

T1 - Neutralizing Antibody Immune Correlates for a Recombinant Protein Vaccine in the COVAIL Trial

AU - Coronavirus Variant Immunologic Landscape Trial (COVAIL) Study Team

AU - Fong, Youyi

AU - Dang, Lauren

AU - Zhang, Bo

AU - Fintzi, Jonathan

AU - Chen, Shiyu

AU - Wang, Jing

AU - Rouphael, Nadine G.

AU - Branche, Angela R.

AU - Diemert, David J.

AU - Falsey, Ann R.

AU - Losada, Cecilia

AU - Baden, Lindsey R.

AU - Frey, Sharon E.

AU - Whitaker, Jennifer A.

AU - Little, Susan J.

AU - Kamidani, Satoshi

AU - Walter, Emmanuel B.

AU - Novak, Richard M.

AU - Rupp, Richard

AU - Jackson, Lisa A.

AU - Yu, Chenchen

AU - Magaret, Craig A.

AU - Molitor, Cindy

AU - Borate, Bhavesh

AU - Babu, Tara M.

AU - Kottkamp, Angelica C.

AU - Luetkemeyer, Anne F.

AU - Immergluck, Lilly C.

AU - Presti, Rachel M.

AU - Bäcker, Martín

AU - Winokur, Patricia L.

AU - Mahgoub, Siham M.

AU - Goepfert, Paul A.

AU - Fusco, Dahlene N.

AU - Atmar, Robert L.

AU - Posavad, Christine M.

AU - Mu, Jinjian

AU - Makowski, Mat

AU - Makhene, Mamodikoe K.

AU - Nayak, Seema U.

AU - Roberts, Paul C.

AU - Follmann, Dean

AU - Gilbert, Peter B.

AU - Malkin, Elissa

AU - Bethony, Jeffrey M.

AU - Desrosiers, Aimee

AU - Siegel, Marc

AU - Walsh, Edward

AU - Kingsley, Patrick

AU - Peasley, Michael

AU - Graciaa, Daniel S.

AU - Samaha, Hady

AU - Rebolledo, Paulina A.

AU - Wiley, Zanthia

AU - Sherman, Amy C.

AU - Walsh, Stephen R.

AU - Tong, Alexandra

AU - Rooks, Rebecca

AU - Abate, Getahun

AU - Oikonomopoulou, Zacharoula

AU - Hoft, Daniel F.

AU - Graham, Irene

AU - El Sahly, Hana M.

AU - Keitel, Wendy A.

AU - Mary Healy, C.

AU - Robert Atmar, L.

AU - Susan Little, J.

AU - Thomas Martin, C. S.

AU - Carter, Nicole

AU - Hendrickx, Steven

AU - Anderson, Evan J.

AU - Christina Rostad, A.

AU - Peters, Etza

AU - Smith, Michael J.

AU - Anthony Moody, M.

AU - Schmader, Kenneth E.

AU - Ladner, Benjamin G.

AU - Wendrow, Andrea

AU - Herrick, Jessica

AU - Porterfield, Laura

AU - Dunstan, Maya

AU - Lau, Rebecca

AU - Carste, Barbara

AU - Wald, Anna

AU - Krause, Taylor

AU - Hauge, Kirsten

AU - Mulligan, Mark J.

AU - Davis, Tamia

AU - Engelson, Celia

AU - Soma, Vijaya

AU - Harris, Chloe

AU - Lopez, Azquena Munoz

AU - Johnson, Erica

AU - Chan, Austin

AU - O'Halloran, Jane A.

AU - Thompson, Ryley M.

AU - Fleming, Andrew B.

AU - Noor, Asif

AU - Meier, Jeffery

AU - Stapleton, Jack

AU - Maxwell, Celia

AU - Shami, Sarah

AU - Drouin, Arnaud C.

AU - Numbi, Florice K.

AU - Lyke, Kirsten E.

AU - Stephens, David S.

AU - Neuzil, Kathleen M.

AU - Farley, Monica M.

AU - Marrazzo, Jeanne

AU - Young, Sidnee Paschal

AU - Lennox, Jeffery

AU - McNeil, Linda

AU - Brown, Elizabeth

AU - Meagher, Megan A.

AU - McElrath, Julie

AU - Gale, Mike

AU - Abebe, Kuleni

AU - Hill, Heather

AU - Albert, Jim

AU - Baughman, Holly

AU - McQuarrie, Lisa

AU - Telu, Kalyani

AU - McQuarrie, Lisa J.

AU - Lewis, Teri C.

AU - Giebeig, Lisa A.

AU - Engel, Theresa M.

AU - Griffith, Caleb J.

AU - McDonald, Wendi L.

AU - Burkey, Alissa E.

AU - Hoopengardner, Lisa B.

AU - Linton, Jessica E.

AU - Gettinger, Nikki L.

AU - Montefiori, David C.

AU - Eaton, Amanda

AU - Smith, Derek J.

AU - Netzl, Antonia

AU - Wilks, Samuel H.

AU - Türeli, Sina

AU - Makhene, Mamodikoe

AU - Elsafy, Mohamed

AU - Pikaart-Tautges, Rhonda

AU - Arega, Janice

AU - Hoang, Binh

AU - Curtin, Dan

AU - Koo, Hyung

AU - Sindall, Elisa

AU - Crandon, Sonja

AU - Degrace, Marciela M.

AU - Post, Diane J.

AU - Beigel, John H.

AU - Ackerley, Cassie Grimsley

AU - Unterberger, Kristen E.

AU - Anderson, Amy

AU - Atha, Mary

AU - Bechnak, Kareem

AU - Bechnak, Sarah

AU - Bower, Mary

AU - Clegg, Laura

AU - Collins, Matthew

AU - Dyer, Francine

AU - Edupuganti, Srilatha

AU - Fineman, Rebecca

AU - Girmay, Tigisty

AU - Gonzalez, Rebecca

AU - Gray, Natalie

AU - Gutter, Evan

AU - Harewood, Lisa

AU - Huerta, Chris

AU - Johnson, Brandi

AU - Johnson, Lauren

AU - Kelley, Colleen

AU - Koumanelis, Alexandra

AU - Laryea, Deborah

AU - MacEnczak, Hollie

AU - Makkaoui, Nour

AU - McCullough, Michele

AU - Ngo, Tuong Vy

AU - Osinski, Eileen

AU - Paine, Julia

AU - Panganiban, Bernadine

AU - Pope, Rose

AU - Rebolledo, Paulina

AU - Rogers, Susan

AU - Scherer, Erin

AU - Smith, Veronica

AU - Stringer, Andre

AU - Traenkner, Jessica

AU - Wang, Dongli

AU - Watson, Alahna

AU - Wheeler, Stacey

AU - Winter, Jean

AU - Xu, Jianguo

AU - Kleinjan, Jane A.

AU - Gothing, Jon A.

AU - Avila Paz, Andres A.

AU - Aleissa, Muneerah M.

AU - Evans, Bethany

AU - Heithoff, August

AU - Izaguirre, Natalie E.

AU - Klebert, Michael

PY - 2025/1/15

Y1 - 2025/1/15

N2 - For COVAIL recipients of a coronavirus disease 2019 (COVID-19) Sanofi booster vaccine, neutralizing antibody titers were assessed as a correlate of risk (CoR) of COVID-19. Peak and exposure-proximal titers were inverse CoRs with covariate-adjusted hazard ratios (95% confidence intervals) 0.30 (0.11, 0.78) and 0.25 (0.07, 0.85) per 10-fold increase in weighted average titer.

AB - For COVAIL recipients of a coronavirus disease 2019 (COVID-19) Sanofi booster vaccine, neutralizing antibody titers were assessed as a correlate of risk (CoR) of COVID-19. Peak and exposure-proximal titers were inverse CoRs with covariate-adjusted hazard ratios (95% confidence intervals) 0.30 (0.11, 0.78) and 0.25 (0.07, 0.85) per 10-fold increase in weighted average titer.

KW - COVID-19 booster

KW - Omicron

KW - correlate of risk

KW - exposure-proximal titer

KW - variant vaccine booster

UR - https://www.scopus.com/pages/publications/85218167493

U2 - 10.1093/cid/ciae465

DO - 10.1093/cid/ciae465

M3 - Article

C2 - 39325506

AN - SCOPUS:85218167493

SN - 1058-4838

VL - 80

SP - 223

EP - 227

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

IS - 1

ER -

Neutralizing Antibody Immune Correlates for a Recombinant Protein Vaccine in the COVAIL Trial

Abstract

Keywords

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