Neurturin, a relative of glial-cell-line-derived neurotrophic factor

Paul T. Kotzbauer, Patricia A. Lampe, Robert O. Heuckeroth, Judith P. Golden, Douglas J. Creedon, Eugene M. Johnson, Jeffrey Milbrandt

Research output: Contribution to journalArticlepeer-review

615 Scopus citations

Abstract

THE normal development of the vertebrate nervous system entails the death of 30-70% of the neurons originally generated in most neuronal populations. This naturally occurring cell death is regulated by specific neurotrophic factors that promote neuronal survival and which are produced in limiting quantities by target cells, glial cells and neurons. These factors are also of potential utility as therapeutic agents for neurodegenerative diseases. Here we describe the purification and cloning of a new neurotrophic factor, identified on the basis of its ability to support the survival of sympathetic neurons in culture. This factor, neurturin, is structurally related to glial-cell-line-derived neurotrophic factor (GDNF). These factors can each activate the MAP kinase signalling pathway in cultured sympathetic neurons and support the survival of sympathetic neurons, as well as of sensory neurons of the nodose and dorsal root ganglia. Thus, neurturin and GDNF together now define a new family of neurotrophic factors.

Original languageEnglish
Pages (from-to)467-470
Number of pages4
JournalNature
Volume384
Issue number6608
DOIs
StatePublished - Dec 5 1996

Fingerprint Dive into the research topics of 'Neurturin, a relative of glial-cell-line-derived neurotrophic factor'. Together they form a unique fingerprint.

Cite this