TY - JOUR
T1 - Neurotrophin regulation of gene expression
AU - Bonni, Azad
AU - Greenberg, Michael E.
PY - 1997/11
Y1 - 1997/11
N2 - The neurotrophins comprise a family of secreted proteins that elicit profound responses in cells of the developing and mature vertebrate nervous system including the regulation of neuronal survival and differentiation. The molecular mechanisms by which the neurotrophins exert their effects have been the subject of intense investigation. The neurotrophins elicit responses in neurons via members of the Trk family of receptors and the p75 neurotrophin receptor. Once activated, neurotrophin receptors trigger a large number of biochemical events that propagate the neurotrophin signal from the plasma membrane to the interior of the cell. An important target of the neurotrophin-induced signaling pathways is the nucleus, where neurotrophin- induced signals are coupled to alterations in gene expression. These neurotrophin-induced changes in gene expression are critical for many of the phenotypic effects of neurotrophins including the regulation of neuronal survival and differentiation.
AB - The neurotrophins comprise a family of secreted proteins that elicit profound responses in cells of the developing and mature vertebrate nervous system including the regulation of neuronal survival and differentiation. The molecular mechanisms by which the neurotrophins exert their effects have been the subject of intense investigation. The neurotrophins elicit responses in neurons via members of the Trk family of receptors and the p75 neurotrophin receptor. Once activated, neurotrophin receptors trigger a large number of biochemical events that propagate the neurotrophin signal from the plasma membrane to the interior of the cell. An important target of the neurotrophin-induced signaling pathways is the nucleus, where neurotrophin- induced signals are coupled to alterations in gene expression. These neurotrophin-induced changes in gene expression are critical for many of the phenotypic effects of neurotrophins including the regulation of neuronal survival and differentiation.
UR - http://www.scopus.com/inward/record.url?scp=0031424306&partnerID=8YFLogxK
U2 - 10.1017/S0317167100032935
DO - 10.1017/S0317167100032935
M3 - Review article
C2 - 9398973
AN - SCOPUS:0031424306
VL - 24
SP - 272
EP - 283
JO - Canadian Journal of Neurological Sciences
JF - Canadian Journal of Neurological Sciences
SN - 0317-1671
IS - 4
ER -