TY - JOUR
T1 - Neurotransmitter modulation of steroid action in target cells that mediate reproduction and reproductive behavior
AU - Nock, Bruce
AU - Feder, Harvey H.
N1 - Funding Information:
Supported by NIH Research Grant HD-04467/09. NIMH Career Development Award MH-29006 and a grant from the Busch Foundation, Rutgers University (all to HHF). BN was supported by Training Grant NIMH 15145-03. Contribution nu~ 215 of the Institute of Animal Behavior. We thank Lynn O'Connor for helpful discussion concerning all aspects of the preparation of this manuscript and Winona Cunninllham and Nancy \]achim for typing. We also thank Cynthia Banas for preparation of the figures.
PY - 1981
Y1 - 1981
N2 - Two major functional interactions between steroid hormones and neurotransmitters are generally recognized. First, steroids affect neurotransmission, and second, through effects on hypothalamic peptides that regulate anterior pituitary function neurotransmitters affect steroid secretion. In recent years, evidence has accumulated which indicates that neurotransmitters can also affect steroid action within postsynaptic steroid target cells. We review evidence for this relationship in pineal, uterus and hypothalamus and propose that the modulation of target cell responsiveness to steroids is an important mechanism by which neurotransmitters affect steroid-dependent processes. The operation of such a mechanism provides a means for environmental, behavioral and emotional events to rapidly and selectively alter steroid effects on behavior and physiology.
AB - Two major functional interactions between steroid hormones and neurotransmitters are generally recognized. First, steroids affect neurotransmission, and second, through effects on hypothalamic peptides that regulate anterior pituitary function neurotransmitters affect steroid secretion. In recent years, evidence has accumulated which indicates that neurotransmitters can also affect steroid action within postsynaptic steroid target cells. We review evidence for this relationship in pineal, uterus and hypothalamus and propose that the modulation of target cell responsiveness to steroids is an important mechanism by which neurotransmitters affect steroid-dependent processes. The operation of such a mechanism provides a means for environmental, behavioral and emotional events to rapidly and selectively alter steroid effects on behavior and physiology.
KW - Hypothalamus
KW - Lordosis
KW - Mechanism of steroid action
KW - Neurotransmitters
KW - Noradrenergic transmission
KW - Pineal
KW - Reproductive behavior
KW - Reproductive physiology
KW - Steroid hormones
KW - Steroid receptors
KW - Steroid-neurotransmitter interaction
KW - Uterus
UR - http://www.scopus.com/inward/record.url?scp=0019823080&partnerID=8YFLogxK
U2 - 10.1016/0149-7634(81)90014-2
DO - 10.1016/0149-7634(81)90014-2
M3 - Article
C2 - 6119663
AN - SCOPUS:0019823080
SN - 0149-7634
VL - 5
SP - 437
EP - 447
JO - Neuroscience and Biobehavioral Reviews
JF - Neuroscience and Biobehavioral Reviews
IS - 4
ER -