TY - JOUR
T1 - Neurotoxicity of Intravenously Administered Penicillin G
AU - Raichle, Marcus E.
AU - Kutt, Henn
AU - Louis, Sydney
AU - Mcdowell, Fletcher
PY - 1971/9
Y1 - 1971/9
N2 - Penicillin G, 20 million units daily given intravenously to a nonuremic patient, caused encephalopathy (progressive restlessness, confusion, hallucinations, and multifocal myoclonus) followed by recovery after discontinuation of the drug. In normal awake cats doses up to 1.3 million units/ kg produced encephalopathy with myoclonus; higher doses culminated in status epilepticus and death. Pretreatment with small doses minimized the effects of a subsequent high dose. In awake rats 4.5 to 5 million units/kg produced encephalopathy resulting in death of the majority of animals. In rats anesthetized with ether, same results were obtained with 3 to 3.5 million units/kg. The highest concentrations of labeled penicillin G in brain, located mostly in membranal-nuclear fraction, was reached in five to ten minutes. The penicillin encephalopathy was reversed in animals by intravenously administered penicillinase.
AB - Penicillin G, 20 million units daily given intravenously to a nonuremic patient, caused encephalopathy (progressive restlessness, confusion, hallucinations, and multifocal myoclonus) followed by recovery after discontinuation of the drug. In normal awake cats doses up to 1.3 million units/ kg produced encephalopathy with myoclonus; higher doses culminated in status epilepticus and death. Pretreatment with small doses minimized the effects of a subsequent high dose. In awake rats 4.5 to 5 million units/kg produced encephalopathy resulting in death of the majority of animals. In rats anesthetized with ether, same results were obtained with 3 to 3.5 million units/kg. The highest concentrations of labeled penicillin G in brain, located mostly in membranal-nuclear fraction, was reached in five to ten minutes. The penicillin encephalopathy was reversed in animals by intravenously administered penicillinase.
KW - PenicillinG
KW - encephalopathy
KW - multifocal myoclonus
KW - nonuremic subjects
KW - penicillinase
KW - status epilepticus
UR - http://www.scopus.com/inward/record.url?scp=0015112972&partnerID=8YFLogxK
U2 - 10.1001/archneur.1971.00490030058006
DO - 10.1001/archneur.1971.00490030058006
M3 - Article
C2 - 4951946
AN - SCOPUS:0015112972
SN - 0003-9942
VL - 25
SP - 232
EP - 239
JO - Archives of neurology
JF - Archives of neurology
IS - 3
ER -