Neurostimulation for depression in epilepsy

Charles R. Conway, Anita Udaiyar, Steven C. Schachter

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations


Epilepsy is often associated with comorbid psychiatric illnesses that can significantly impact its long-term course. The most frequent of these psychiatric comorbidities is major depressive disorder, which affects an estimated 40% of patients with epilepsy. Many patients are underdiagnosed or undertreated, yet managing their mood symptoms is critical to improving their outcomes. When conventional psychiatric treatments fail in the management of depression, neuromodulation techniques may offer promise, including electroconvulsive therapy (ECT), vagus nerve stimulation (VNS), and repetitive transcranial magnetic stimulation (rTMS), as discussed in this review. “This article is part of the Supplement issue Neurostimulation for Epilepsy.”

Original languageEnglish
Pages (from-to)25-32
Number of pages8
JournalEpilepsy and Behavior
StatePublished - Nov 2018


  • Electroconvulsive therapy
  • Epilepsy
  • Major depression
  • Neuromodulation
  • Repetitive transcranial magnetic stimulation
  • Vagus nerve stimulation


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