Neurosteroids in pain management: A new perspective on an old player

Sonja L. Joksimovic, Douglas F. Covey, Vesna Jevtovic-Todorovic, Slobodan M. Todorovic

Research output: Contribution to journalReview article

7 Scopus citations

Abstract

Since the discovery of the nervous system's ability to produce steroid hormones, numerous studies have demonstrated their importance in modulating neuronal excitability. These central effects are mostly mediated through different ligand-gated receptor systems such as GABAA and NMDA, as well as voltage-dependent Ca2+ or K+ channels. Because these targets are also implicated in transmission of sensory information, it is not surprising that numerous studies have shown the analgesic properties of neurosteroids in various pain models. Physiological (nociceptive) pain has protective value for an organism by promoting survival in life-threatening conditions. However, more prolonged pain that results from dysfunction of nerves (neuropathic pain), and persists even after tissue injury has resolved, is one of the main reasons that patients seek medical attention. This review will focus mostly on the analgesic perspective of neurosteroids and their synthetic 5α and 5β analogs in nociceptive and neuropathic pain conditions.

Original languageEnglish
Article number1127
JournalFrontiers in Pharmacology
Volume9
Issue numberOCT
DOIs
StatePublished - Oct 2 2018

Keywords

  • Analgesic (activity)
  • Chronic pain
  • Neurosteroid analogs
  • Neurosteroids
  • T-channel (CaV3)
  • T-channel calcium channel blockers

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