The synthesis of (3β,5β,8α,9β,10α,13α14β,17α)-3- hydroxypregnan-20-one 2, (3β,5β,8α,9β,10α,13α,14β,17α)-3- hydroxyandrostane-17-carbonitrile 4,†[3R-(3α,3aα,5aβ,7α,9bβ)]-1-[dodecahydro-7- (2-hydroxyethyl)-3a-methyl-1H-benz[e]inden-3-yl]ethanone 6 and [3R-(3α,3aα,5aβ,7α,9aα,9bβ)]-dodecahydro-7-(2- hydroxyethyl)-3a-methyl-1H-benz[e]indene-3-carbonitrile 8 is reported. ‡ Steroids 2 and 4 have been used previously to investigate the enantioselectivity of steroid action on GABAA receptor function and to correlate steroid action at this receptor with the anesthetic actions of the compounds. The enantioselective actions of benz[e]indenes 6 and 8 have been evaluated for the same reasons in this study. Similar correlations between the enantioselective effects of both classes of compounds on GABAA receptor function and anesthetic potency in tadpoles have been observed.
|Number of pages||7|
|Journal||Journal of the Chemical Society - Perkin Transactions 1|
|State||Published - Dec 21 1997|