Neurosensory perception of environmental cues modulates sperm motility critical for fertilization

Katherine McKnight, Hieu D. Hoang, Jeevan K. Prasain, Naoko Brown, Jack Vibbert, Kyle A. Hollister, Ray Moore, Justin R. Ragains, Jeff Reese, Michael A. Miller

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

Environmental exposures affect gamete function and fertility, but the mechanisms are poorly understood. Here, we show that pheromones sensed by ciliated neurons in the Caenorhabditis elegans nose alter the lipid microenvironment within the oviduct, thereby affecting sperm motility. In favorable environments, pheromone-responsive sensory neurons secrete a transforming growth factor-β ligand called DAF-7, which acts as a neuroendocrine factor that stimulates prostaglandin-endoperoxide synthase [cyclooxygenase (Cox)]-independent prostaglandin synthesis in the ovary. Oocytes secrete F-class prostaglandins that guide sperm toward them. These prostaglandins are also synthesized in Cox knockout mice, raising the possibility that similar mechanisms exist in other animals. Our data indicate that environmental cues perceived by the female nervous system affect sperm function.

Original languageEnglish
Pages (from-to)754-757
Number of pages4
JournalScience
Volume344
Issue number6185
DOIs
StatePublished - 2014

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