TY - JOUR
T1 - Neuropsychologic deficits in children with sickle cell disease and cerebral infarction
T2 - Role of lesion site and volume
AU - Schatz, Jeffrey
AU - Craft, Suzanne
AU - Koby, Myles
AU - Siegel, Marilyn J.
AU - Resar, Linda
AU - Lee, Roland R.
AU - Chu, Jen Yih
AU - Launius, Greg
AU - Dadash-Zadehm, Mahboubeh
AU - DeBaun, Michael R.
PY - 1999
Y1 - 1999
N2 - Little is known about the correlation between the location and size of cerebral infarction in children and neuropsychologic deficits. We related lesion location and volume on magnetic resonance exams to neuropsychologic performance in 28 children with cerebral infarcts due to sickle cell disease. Seventeen healthy siblings served as a comparison group. Children with anterior cerebral infarcts (n = 7) showed deficits in attention and executive skills, whereas children with more widespread cerebral infarcts (n = 18) showed additional deficits in spatial skills. The volume of cerebral infarction was associated with spatial and language performance, but minimally related to performance in other cognitive domains. The location and volume of cerebral infarction are both important for defining the type and magnitude of cognitive sequelae in childhood stroke.
AB - Little is known about the correlation between the location and size of cerebral infarction in children and neuropsychologic deficits. We related lesion location and volume on magnetic resonance exams to neuropsychologic performance in 28 children with cerebral infarcts due to sickle cell disease. Seventeen healthy siblings served as a comparison group. Children with anterior cerebral infarcts (n = 7) showed deficits in attention and executive skills, whereas children with more widespread cerebral infarcts (n = 18) showed additional deficits in spatial skills. The volume of cerebral infarction was associated with spatial and language performance, but minimally related to performance in other cognitive domains. The location and volume of cerebral infarction are both important for defining the type and magnitude of cognitive sequelae in childhood stroke.
UR - https://www.scopus.com/pages/publications/0032860859
U2 - 10.1076/chin.5.2.92.3170
DO - 10.1076/chin.5.2.92.3170
M3 - Article
AN - SCOPUS:0032860859
SN - 0929-7049
VL - 5
SP - 92
EP - 103
JO - Child Neuropsychology
JF - Child Neuropsychology
IS - 2
ER -