Abstract
We examined whether neuropsychiatric symptoms (NPS) interact with cerebrospinal fluid (CSF) biomarkers (amyloid-β42 [Aβ42], tau, phosphorylated tau181 [ptau181], tau/Aβ42, and ptau181/Aβ42) of Alzheimer's disease pathology to predict driving decline among cognitively-normal older adults (N=116) aged ≥65. Cox proportional hazards models examined time to receiving a rating of marginal or fail on the driving test. Age, education, and gender were adjusted in the models. Participants with more abnormal CSF (Aβ42, tau/Aβ42, ptau181/Aβ42) and NPS were faster to receive a marginal/fail on the road test compared to those without NPS. NPS interact with abnormal CSF biomarkers to impact driving performance among cognitively-normal older adults.
Original language | English |
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Pages (from-to) | 675-680 |
Number of pages | 6 |
Journal | Journal of Alzheimer's Disease |
Volume | 58 |
Issue number | 3 |
DOIs | |
State | Published - 2017 |
Keywords
- Alzheimer's disease
- cerebrospinal fluid
- depression
- neuropsychology
- noncognitive outcomes
- preclinical