Neuropsychiatric Symptoms and Alzheimer's Disease Biomarkers Predict Driving Decline: Brief Report

Ganesh M. Babulal; Sarah H. Stout; Denise Head; David M. Holtzman; Anne M. Fagan; John C. Morris; Catherine M. Roe

doi:10.3233/JAD-170067

Neuropsychiatric Symptoms and Alzheimer's Disease Biomarkers Predict Driving Decline: Brief Report

Ganesh M. Babulal, Sarah H. Stout, Denise Head, David M. Holtzman, Anne M. Fagan, John C. Morris, Catherine M. Roe

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

We examined whether neuropsychiatric symptoms (NPS) interact with cerebrospinal fluid (CSF) biomarkers (amyloid-β₄₂ [Aβ₄₂], tau, phosphorylated tau₁₈₁ [ptau₁₈₁], tau/Aβ₄₂, and ptau₁₈₁/Aβ₄₂) of Alzheimer's disease pathology to predict driving decline among cognitively-normal older adults (N=116) aged ≥65. Cox proportional hazards models examined time to receiving a rating of marginal or fail on the driving test. Age, education, and gender were adjusted in the models. Participants with more abnormal CSF (Aβ₄₂, tau/Aβ₄₂, ptau₁₈₁/Aβ₄₂) and NPS were faster to receive a marginal/fail on the road test compared to those without NPS. NPS interact with abnormal CSF biomarkers to impact driving performance among cognitively-normal older adults.

Original language	English
Pages (from-to)	675-680
Number of pages	6
Journal	Journal of Alzheimer's Disease
Volume	58
Issue number	3
DOIs	https://doi.org/10.3233/JAD-170067
State	Published - 2017

Keywords

Alzheimer's disease
cerebrospinal fluid
depression
neuropsychology
noncognitive outcomes
preclinical

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10.3233/JAD-170067

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title = "Neuropsychiatric Symptoms and Alzheimer's Disease Biomarkers Predict Driving Decline: Brief Report",

abstract = "We examined whether neuropsychiatric symptoms (NPS) interact with cerebrospinal fluid (CSF) biomarkers (amyloid-β42 [Aβ42], tau, phosphorylated tau181 [ptau181], tau/Aβ42, and ptau181/Aβ42) of Alzheimer's disease pathology to predict driving decline among cognitively-normal older adults (N=116) aged ≥65. Cox proportional hazards models examined time to receiving a rating of marginal or fail on the driving test. Age, education, and gender were adjusted in the models. Participants with more abnormal CSF (Aβ42, tau/Aβ42, ptau181/Aβ42) and NPS were faster to receive a marginal/fail on the road test compared to those without NPS. NPS interact with abnormal CSF biomarkers to impact driving performance among cognitively-normal older adults.",

keywords = "Alzheimer's disease, cerebrospinal fluid, depression, neuropsychology, noncognitive outcomes, preclinical",

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AU - Babulal, Ganesh M.

AU - Stout, Sarah H.

AU - Head, Denise

AU - Holtzman, David M.

AU - Fagan, Anne M.

AU - Morris, John C.

AU - Roe, Catherine M.

PY - 2017

Y1 - 2017

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AB - We examined whether neuropsychiatric symptoms (NPS) interact with cerebrospinal fluid (CSF) biomarkers (amyloid-β42 [Aβ42], tau, phosphorylated tau181 [ptau181], tau/Aβ42, and ptau181/Aβ42) of Alzheimer's disease pathology to predict driving decline among cognitively-normal older adults (N=116) aged ≥65. Cox proportional hazards models examined time to receiving a rating of marginal or fail on the driving test. Age, education, and gender were adjusted in the models. Participants with more abnormal CSF (Aβ42, tau/Aβ42, ptau181/Aβ42) and NPS were faster to receive a marginal/fail on the road test compared to those without NPS. NPS interact with abnormal CSF biomarkers to impact driving performance among cognitively-normal older adults.

KW - Alzheimer's disease

KW - cerebrospinal fluid

KW - depression

KW - neuropsychology

KW - noncognitive outcomes

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Neuropsychiatric Symptoms and Alzheimer's Disease Biomarkers Predict Driving Decline: Brief Report

Abstract

Keywords

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