@article{230b87e31b1f4d1a8eb451c9b768f9ac,
title = "Neuropsychiatric Symptoms and Alzheimer's Disease Biomarkers Predict Driving Decline: Brief Report",
abstract = "We examined whether neuropsychiatric symptoms (NPS) interact with cerebrospinal fluid (CSF) biomarkers (amyloid-β42 [Aβ42], tau, phosphorylated tau181 [ptau181], tau/Aβ42, and ptau181/Aβ42) of Alzheimer's disease pathology to predict driving decline among cognitively-normal older adults (N=116) aged ≥65. Cox proportional hazards models examined time to receiving a rating of marginal or fail on the driving test. Age, education, and gender were adjusted in the models. Participants with more abnormal CSF (Aβ42, tau/Aβ42, ptau181/Aβ42) and NPS were faster to receive a marginal/fail on the road test compared to those without NPS. NPS interact with abnormal CSF biomarkers to impact driving performance among cognitively-normal older adults.",
keywords = "Alzheimer's disease, cerebrospinal fluid, depression, neuropsychology, noncognitive outcomes, preclinical",
author = "Babulal, {Ganesh M.} and Stout, {Sarah H.} and Denise Head and Holtzman, {David M.} and Fagan, {Anne M.} and Morris, {John C.} and Roe, {Catherine M.}",
note = "Funding Information: The National Institute on Aging [R01-AG043434, P50-AG05681, P01-AG03991, P01-AG026276]; Fred Simmons and Olga Mohan, and the Charles and Joanne Knight Alzheimer's Research Initiative of the Washington University Knight Alzheimer's Disease Research Center (ADRC). The authors thank the participants, investigators, and staff of the Knight ADRC Clinical Core (participant assessments), the investigators and staff of the Driving Performance in Preclinical Alzheimer's Disease study (R01-AG043434), and the investigators and staff of the Biomarker Core for the Adult Children Study (P01-AG026276) for cerebrospinal fluid analysis. Funding for this study was provided by the National Institute on Aging [R01-AG043434, P50-AG05681, P01-AG03991, P01-AG026276]; Fred Simmons and Olga Mohan, and the Charles and Joanne Knight Alzheimer's Research Initiative of the Washington University Knight Alzheimer's Disease Research Center. Publisher Copyright: {\textcopyright} 2017 - IOS Press and the authors. All rights reserved.",
year = "2017",
doi = "10.3233/JAD-170067",
language = "English",
volume = "58",
pages = "675--680",
journal = "Journal of Alzheimer's Disease",
issn = "1387-2877",
number = "3",
}