Neuroprotective aspects of a novel MAO-B inhibitor PF9601N

V. Pérez, J. Morón, M. Pastó, M. Unzeta

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


PF9601N is an acetylenic tryptamine derivative devoid of amphetamine-like properties, that behaves as suicide MAO-B inhibitor more potent than 1-deprenyl. It is highly selective towards MAO-B and it neuroprotects from the neurotoxicity induced in C57B1/6 adult mice by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). PF9601N also shows in vitro antioxidant properties by inhibiting the dopamine autoxidation. A potential therapeutic use in Parkinson's disease treatment is proposed for this compound.

Original languageEnglish
Pages (from-to)231-236
Number of pages6
Issue number3-4
StatePublished - Dec 1 2000


  • Antioxidative
  • MAO-B inhibitor
  • Neuroprotection


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