Neuroprotective aspects of a novel MAO-B inhibitor PF9601N

V. Pérez; J. Morón; M. Pastó; M. Unzeta

Neuroprotective aspects of a novel MAO-B inhibitor PF9601N

V. Pérez, J. Morón, M. Pastó, M. Unzeta

Research output: Contribution to journal › Article › peer-review

Abstract

PF9601N is an acetylenic tryptamine derivative devoid of amphetamine-like properties, that behaves as suicide MAO-B inhibitor more potent than 1-deprenyl. It is highly selective towards MAO-B and it neuroprotects from the neurotoxicity induced in C57B1/6 adult mice by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). PF9601N also shows in vitro antioxidant properties by inhibiting the dopamine autoxidation. A potential therapeutic use in Parkinson's disease treatment is proposed for this compound.

Original language	English
Pages (from-to)	231-236
Number of pages	6
Journal	Neurobiology
Volume	8
Issue number	3-4
State	Published - Dec 1 2000

Keywords

Antioxidative
MAO-B inhibitor
Neuroprotection

Cite this

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AU - Morón, J.

AU - Pastó, M.

AU - Unzeta, M.

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N2 - PF9601N is an acetylenic tryptamine derivative devoid of amphetamine-like properties, that behaves as suicide MAO-B inhibitor more potent than 1-deprenyl. It is highly selective towards MAO-B and it neuroprotects from the neurotoxicity induced in C57B1/6 adult mice by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). PF9601N also shows in vitro antioxidant properties by inhibiting the dopamine autoxidation. A potential therapeutic use in Parkinson's disease treatment is proposed for this compound.

AB - PF9601N is an acetylenic tryptamine derivative devoid of amphetamine-like properties, that behaves as suicide MAO-B inhibitor more potent than 1-deprenyl. It is highly selective towards MAO-B and it neuroprotects from the neurotoxicity induced in C57B1/6 adult mice by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). PF9601N also shows in vitro antioxidant properties by inhibiting the dopamine autoxidation. A potential therapeutic use in Parkinson's disease treatment is proposed for this compound.

KW - Antioxidative

KW - MAO-B inhibitor

KW - Neuroprotection

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JO - Neurobiology

JF - Neurobiology

IS - 3-4

ER -

Neuroprotective aspects of a novel MAO-B inhibitor PF9601N

Abstract

Keywords

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