10 Scopus citations


The ability to cope with ongoing neurodegeneration after injury to the central nervous system of mammals differs among strains and depends in part on the animal's ability to manifest a T-cell-mediated protective response. After CNS injury, strain-related differences were observed. Moreover, the post-injury effect of naturally occurring regulatory CD4+CD25+ T cells was found to differ in different strains. In this study, using partially injured optic nerves of Balb/c/OLA and C57BL/6J mice as models, we observed strain-related differences in the T-cell-mediated protection obtained by antigens administered via the nasal route. Active immunization with myelin-related antigens emulsified in complete Freund's adjuvant had a beneficial effect on both strains, whereas mucosal administration of the same antigens was destructive in mice of the Balb/c/OLA strain but protective in C57BL/6J mice.

Original languageEnglish
Pages (from-to)31-38
Number of pages8
JournalJournal of Neuroimmunology
Issue number1-2
StatePublished - Jun 2006


  • Autoimmunity
  • Mucosal tolerance
  • Neurodegeneration
  • Neuroimmunology
  • T cells


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