Neuroprotection by dehydroepiandrosteronesulfate: Role of an NF≃B-like factor

Xianrong Mao, Steven W. Barger

Research output: Contribution to journalArticlepeer-review

102 Scopus citations

Abstract

Levels of dehydroepiandrosterone (DHEA) and its sulfated derivative (DHEA-S) decline during aging and reach even lower levels in Alzheimer's disease (AD). Previously published effects of DHEA and DHEA-S on unchallenged neuronal survival led us to test them in an excitotoxicity paradigm. While DHEA-S protected hippocampal neurons against glutamate, little protection was observed with equivalent doses of DHEA itself. This differential neuroprotection was consistent with the ability of DHEA-S (but not DHEA) to elevate a κB-dependent transcription factor activity, a phenomenon we previously have connected with neuroprotection. Furthermore, suppression of κB DNA-binding by 'decoy' oligonucleotides blocked the neuroprotective activity of DHEA-S. These findings imply that age-related declines in the availability of DHEA-S could exacerbate neurotoxicity, and the data suggest that therapeutic gains may be obtained with pharmacological manipulation of κB-dependent transcription in neurons.

Original languageEnglish
Pages (from-to)759-763
Number of pages5
JournalNeuroReport
Volume9
Issue number4
DOIs
StatePublished - Mar 9 1998

Keywords

  • Cell culture
  • DHEA
  • Excitotoxicity
  • Hippocampus
  • NFκB

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