Neurophysiological Correlates of Fatigue in Multiple Sclerosis

Pamela Newland, Ling Chen, Peng Sun, John Zempel

Research output: Contribution to journalArticlepeer-review


Examining fatigue may be beneficial for nurse practitioners to intervene in the care of patients with multiple sclerosis (MS). We measured the relationship of fatigue severity with event-related potentials during electroencephalogram and diffusion basis spectrum imaging/magnetic resonance imaging in 11 participants with relapsing-remitting MS and 5 healthy controls. Data were analyzed to measure brain activity during event-related potentials to responses to cue (correct response) and distractor (incorrect response) using a cognitive performance task. Nurse practitioners caring for patients with MS have an important role in monitoring fatigue severity.

Original languageEnglish
Pages (from-to)883-888
Number of pages6
JournalJournal for Nurse Practitioners
Issue number7
StatePublished - Jul 1 2021


  • Fatigue Severity Scale
  • attention
  • brain response
  • event related potentials
  • fatigue severity
  • multiple sclerosis


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