Neuropathic Pain Following Surgery

Simon Haroutounian, Troels Staehelin Jensen

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Persistent postsurgical pain (PPSP) is a common consequence of numerous surgical procedures, especially those involving potential nerve injuries. With more than 200 million surgical procedures performed each year globally, PPSP is a significant cause of disability worldwide. The exact mechanism of PPSP is not clear, but it is assumed that changes both at the peripheral tissue injury site and central neuroplasticity following the peripheral injury contribute to the condition. As PPSP is iatrogenic and may be entirely preventable, substantial research in the last two decades has focused on identifying pre-, intra-, and postoperative PPSP risk factors and on developing pharmacological and interventional approaches to reduce the incidence of this condition. This chapter summarizes the current evidence on epidemiology, risk factors and mechanisms of neuropathic pain following surgery, and discusses the approaches for its prevention and treatment.

Original languageEnglish
Title of host publicationPain, Treatment, Injury, Disease and Future Directions
Number of pages15
ISBN (Electronic)9780128026953
ISBN (Print)9780128026533
StatePublished - Apr 23 2015


  • Nerve injury
  • Neuropathic pain
  • Persistent postsurgical pain
  • Preemptive analgesia
  • Prevention
  • Sensitization

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  • Cite this

    Haroutounian, S., & Jensen, T. S. (2015). Neuropathic Pain Following Surgery. In Pain, Treatment, Injury, Disease and Future Directions (Vol. 2, pp. 113-127). Elsevier.