TY - JOUR
T1 - Neuronal remapping and circuit persistence in economic decisions
AU - Xie, Jue
AU - Padoa-Schioppa, Camillo
N1 - Funding Information:
We thank H. Schoknecht for help with animal training, A. Raghuraman for help with recording and X. Cai, K. Conen, E. Han, I. Monosov and L. Snyder for comments on the manuscript. This work was supported by the National Institutes of Health (grant numbers R01-DA032758 and R01-MH104494 to C.P.-S.) and by the McDonnell Center for Systems Neuroscience (predoctoral fellowship to J.X.).
Publisher Copyright:
© 2016 Nature America, Inc. All rights reserved.
PY - 2016/4/26
Y1 - 2016/4/26
N2 - The orbitofrontal cortex plays a central role in good-based economic decisions. When subjects make choices, neurons in this region represent the identities and values of offered and chosen goods. Notably, choices in different behavioral contexts may involve a potentially infinite variety of goods. Thus a fundamental question concerns the stability versus flexibility of the decision circuit. Here we show in rhesus monkeys that neurons encoding the identity or the subjective value of particular goods in a given context 'remap' and become associated with different goods when the context changes. At the same time, the overall organization of the decision circuit and the function of individual cells remain stable across contexts. In particular, two neurons supporting the same decision in one context also support the same decision in different contexts. These results demonstrate how the same neural circuit can underlie economic decisions involving a large variety of goods.
AB - The orbitofrontal cortex plays a central role in good-based economic decisions. When subjects make choices, neurons in this region represent the identities and values of offered and chosen goods. Notably, choices in different behavioral contexts may involve a potentially infinite variety of goods. Thus a fundamental question concerns the stability versus flexibility of the decision circuit. Here we show in rhesus monkeys that neurons encoding the identity or the subjective value of particular goods in a given context 'remap' and become associated with different goods when the context changes. At the same time, the overall organization of the decision circuit and the function of individual cells remain stable across contexts. In particular, two neurons supporting the same decision in one context also support the same decision in different contexts. These results demonstrate how the same neural circuit can underlie economic decisions involving a large variety of goods.
UR - http://www.scopus.com/inward/record.url?scp=84966670164&partnerID=8YFLogxK
U2 - 10.1038/nn.4300
DO - 10.1038/nn.4300
M3 - Article
C2 - 27159800
AN - SCOPUS:84966670164
SN - 1097-6256
VL - 19
SP - 855
EP - 861
JO - Nature neuroscience
JF - Nature neuroscience
IS - 6
ER -