TY - JOUR
T1 - Neuronal Firing Rate Homeostasis Is Inhibited by Sleep and Promoted by Wake
AU - Hengen, Keith B.
AU - Torrado Pacheco, Alejandro
AU - McGregor, James N.
AU - Van Hooser, Stephen D.
AU - Turrigiano, Gina G.
N1 - Publisher Copyright:
© 2016 Elsevier Inc.
PY - 2016/3/24
Y1 - 2016/3/24
N2 - Summary Homeostatic mechanisms stabilize neural circuit function by keeping firing rates within a set-point range, but whether this process is gated by brain state is unknown. Here, we monitored firing rate homeostasis in individual visual cortical neurons in freely behaving rats as they cycled between sleep and wake states. When neuronal firing rates were perturbed by visual deprivation, they gradually returned to a precise, cell-autonomous set point during periods of active wake, with lengthening of the wake period enhancing firing rate rebound. Unexpectedly, this resetting of neuronal firing was suppressed during sleep. This raises the possibility that memory consolidation or other sleep-dependent processes are vulnerable to interference from homeostatic plasticity mechanisms.
AB - Summary Homeostatic mechanisms stabilize neural circuit function by keeping firing rates within a set-point range, but whether this process is gated by brain state is unknown. Here, we monitored firing rate homeostasis in individual visual cortical neurons in freely behaving rats as they cycled between sleep and wake states. When neuronal firing rates were perturbed by visual deprivation, they gradually returned to a precise, cell-autonomous set point during periods of active wake, with lengthening of the wake period enhancing firing rate rebound. Unexpectedly, this resetting of neuronal firing was suppressed during sleep. This raises the possibility that memory consolidation or other sleep-dependent processes are vulnerable to interference from homeostatic plasticity mechanisms.
UR - http://www.scopus.com/inward/record.url?scp=84961218932&partnerID=8YFLogxK
U2 - 10.1016/j.cell.2016.01.046
DO - 10.1016/j.cell.2016.01.046
M3 - Article
C2 - 26997481
AN - SCOPUS:84961218932
SN - 0092-8674
VL - 165
SP - 180
EP - 191
JO - Cell
JF - Cell
IS - 1
ER -