TY - JOUR
T1 - Neuronal correlates of motor performance and motor learning in the primary motor cortex of monkeys adapting to an external force field
AU - Li, Chiang Shan Ray
AU - Padoa-Schioppa, Camillo
AU - Bizzi, Emilio
N1 - Funding Information:
We thank Brian Benda for participating at an early stage of the present work and Dan DiLorenzo for helping us with the EMG recordings. We are also thankful to Matt Tresch, Andrea d'Avella, Philippe Saltiel, and Emanuel Todorov for helpful discussions and to Lori Markson for editing the manuscript. This study was supported by the NIH grant number MN481185.
PY - 2001
Y1 - 2001
N2 - The primary motor cortex (M1) is known to control motor performance. Recent findings have also implicated M1 in motor learning, as neurons in this area show learning-related plasticity. In the present study, we analyzed the neuronal activity recorded in M1 in a force field adaptation task. Our goal was to investigate the neuronal reorganization across behavioral epochs (before, during, and after adaptation). Here we report two main findings. First, memory cells were present in two classes. With respect to the changes of preferred direction (Pd), these two classes complemented each other after readaptation. Second, for the entire neuronal population, the shift of Pd matched the shift observed for muscles. These results provide a framework whereby the activity of distinct neuronal subpopulations combines to subserve both functions of motor performance and motor learning.
AB - The primary motor cortex (M1) is known to control motor performance. Recent findings have also implicated M1 in motor learning, as neurons in this area show learning-related plasticity. In the present study, we analyzed the neuronal activity recorded in M1 in a force field adaptation task. Our goal was to investigate the neuronal reorganization across behavioral epochs (before, during, and after adaptation). Here we report two main findings. First, memory cells were present in two classes. With respect to the changes of preferred direction (Pd), these two classes complemented each other after readaptation. Second, for the entire neuronal population, the shift of Pd matched the shift observed for muscles. These results provide a framework whereby the activity of distinct neuronal subpopulations combines to subserve both functions of motor performance and motor learning.
UR - http://www.scopus.com/inward/record.url?scp=0034981958&partnerID=8YFLogxK
U2 - 10.1016/S0896-6273(01)00301-4
DO - 10.1016/S0896-6273(01)00301-4
M3 - Article
C2 - 11395017
AN - SCOPUS:0034981958
VL - 30
SP - 593
EP - 607
JO - Neuron
JF - Neuron
SN - 0896-6273
IS - 2
ER -