Neuronal correlates of motor performance and motor learning in the primary motor cortex of monkeys adapting to an external force field

Chiang Shan Ray Li, Camillo Padoa-Schioppa, Emilio Bizzi

Research output: Contribution to journalArticle

308 Scopus citations

Abstract

The primary motor cortex (M1) is known to control motor performance. Recent findings have also implicated M1 in motor learning, as neurons in this area show learning-related plasticity. In the present study, we analyzed the neuronal activity recorded in M1 in a force field adaptation task. Our goal was to investigate the neuronal reorganization across behavioral epochs (before, during, and after adaptation). Here we report two main findings. First, memory cells were present in two classes. With respect to the changes of preferred direction (Pd), these two classes complemented each other after readaptation. Second, for the entire neuronal population, the shift of Pd matched the shift observed for muscles. These results provide a framework whereby the activity of distinct neuronal subpopulations combines to subserve both functions of motor performance and motor learning.

Original languageEnglish
Pages (from-to)593-607
Number of pages15
JournalNeuron
Volume30
Issue number2
DOIs
StatePublished - Jan 1 2001
Externally publishedYes

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