Neuronal activity in brain tumor pathogenesis: Adding to the complexities of central nervous system neoplasia

Khushboo Irshad, Nicole Brossier, Yuan Pan

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

In the central nervous system (CNS), the electrical activity of neurons not only drives neurodevelopment but also influences the behavior of neural stem cells and committed progenitor cells in adulthood. Primary brain tumors are believed to originate from the CNS stem and progenitor cell populations, many of which are modulated by neurons and neuronal activity. In this chapter, we focus on the biology of glioma where most neuronal regulation of brain tumors is studied to date. We first review the putative cellular origins of gliomas and the neuronal regulation of these CNS stem and progenitor cells. Then we discuss how these interactions are subverted by glioma and other brain tumor cells to support cancer progression. We also discuss potential therapeutic interventions to target neuron-cancer interactions in brain tumors.

Original languageEnglish
Title of host publicationCancer Neuroscience
PublisherSpringer International Publishing
Pages3-25
Number of pages23
ISBN (Electronic)9783031324291
ISBN (Print)9783031324284
DOIs
StatePublished - Jul 25 2023

Keywords

  • Brain tumor
  • Central nervous system
  • Neuron-tumor crosstalk
  • Neuronal activity

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