Abstract
In the central nervous system (CNS), the electrical activity of neurons not only drives neurodevelopment but also influences the behavior of neural stem cells and committed progenitor cells in adulthood. Primary brain tumors are believed to originate from the CNS stem and progenitor cell populations, many of which are modulated by neurons and neuronal activity. In this chapter, we focus on the biology of glioma where most neuronal regulation of brain tumors is studied to date. We first review the putative cellular origins of gliomas and the neuronal regulation of these CNS stem and progenitor cells. Then we discuss how these interactions are subverted by glioma and other brain tumor cells to support cancer progression. We also discuss potential therapeutic interventions to target neuron-cancer interactions in brain tumors.
Original language | English |
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Title of host publication | Cancer Neuroscience |
Publisher | Springer International Publishing |
Pages | 3-25 |
Number of pages | 23 |
ISBN (Electronic) | 9783031324291 |
ISBN (Print) | 9783031324284 |
DOIs | |
State | Published - Jul 25 2023 |
Keywords
- Brain tumor
- Central nervous system
- Neuron-tumor crosstalk
- Neuronal activity