TY - JOUR
T1 - Neurologic Complications in Children Hospitalized with Influenza
T2 - Characteristics, Incidence, and Risk Factors
AU - Newland, Jason G.
AU - Laurich, V. Matt
AU - Rosenquist, Anna W.
AU - Heydon, Kateri
AU - Licht, Daniel J.
AU - Keren, Ron
AU - Zaoutis, Theoklis E.
AU - Watson, Barbara
AU - Hodinka, Richard L.
AU - Coffin, Susan E.
N1 - Funding Information:
Supported by a grant from the Centers for Disease Control and Prevention (H23/CCH32253-02). Dr Newland was supported by the Pediatric Infectious Diseases Society–St. Jude’s Children’s Research Hospital Fellowship Program in Basic Research.
PY - 2007/3
Y1 - 2007/3
N2 - Objective: To determine the characteristics, incidence, and risk factors for influenza-related neurologic complications (INC). Study design: A retrospective cohort study of INC in children hospitalized with laboratory-confirmed influenza infection (LCI) from June 2000 to May 2004 was conducted. Systematic chart review was performed to identify clinical characteristics and outcomes. A neighborhood cohort was constructed to estimate the incidence of INC. Logistic regression was used to identify independent risk factors for INC. Results: Of 842 patients with LCI, 72 patients had an INC: influenza-related encephalopathy (8), post-infectious influenza encephalopathy (2), seizures (56), and other (6). Febrile seizures were the most common type of seizures (27). No patient died from an INC. In our neighborhood cohort, the incidence of INC was 4 cases per 100,000 person-years. An age of 6 to 23 months (odds ratio [OR], 4.2; 95% CI, 1.4-12.5) or 2 to 4 years (OR, 6.3; 95% CI, 2.1-19.1) and an underlying neurologic or neuromuscular disease (OR, 5.6; 95% CI, 3.2-9.6) were independent risk factors for the development of INC. Conclusion: Seizures are the most common neurologic complication experienced by children hospitalized with influenza. In the United States, encephalopathy is uncommon. Young children and patients with neurologic or neuromuscular disease are at increased risk for INC.
AB - Objective: To determine the characteristics, incidence, and risk factors for influenza-related neurologic complications (INC). Study design: A retrospective cohort study of INC in children hospitalized with laboratory-confirmed influenza infection (LCI) from June 2000 to May 2004 was conducted. Systematic chart review was performed to identify clinical characteristics and outcomes. A neighborhood cohort was constructed to estimate the incidence of INC. Logistic regression was used to identify independent risk factors for INC. Results: Of 842 patients with LCI, 72 patients had an INC: influenza-related encephalopathy (8), post-infectious influenza encephalopathy (2), seizures (56), and other (6). Febrile seizures were the most common type of seizures (27). No patient died from an INC. In our neighborhood cohort, the incidence of INC was 4 cases per 100,000 person-years. An age of 6 to 23 months (odds ratio [OR], 4.2; 95% CI, 1.4-12.5) or 2 to 4 years (OR, 6.3; 95% CI, 2.1-19.1) and an underlying neurologic or neuromuscular disease (OR, 5.6; 95% CI, 3.2-9.6) were independent risk factors for the development of INC. Conclusion: Seizures are the most common neurologic complication experienced by children hospitalized with influenza. In the United States, encephalopathy is uncommon. Young children and patients with neurologic or neuromuscular disease are at increased risk for INC.
UR - http://www.scopus.com/inward/record.url?scp=33847287697&partnerID=8YFLogxK
U2 - 10.1016/j.jpeds.2006.11.054
DO - 10.1016/j.jpeds.2006.11.054
M3 - Article
C2 - 17307552
AN - SCOPUS:33847287697
SN - 0022-3476
VL - 150
SP - 306
EP - 310
JO - Journal of Pediatrics
JF - Journal of Pediatrics
IS - 3
ER -