TY - JOUR
T1 - Neuroinflammation pet imaging
T2 - Current opinion and future directions
AU - Jain, Poorva
AU - Chaney, Aisling M.
AU - Carlson, Mackenzie L.
AU - Jackson, Isaac M.
AU - Rao, Anoushka
AU - James, Michelle L.
N1 - Publisher Copyright:
© 2020 Society of Nuclear Medicine Inc.. All rights reserved.
PY - 2020/8/1
Y1 - 2020/8/1
N2 - Neuroinflammation is a key pathologic hallmark of numerous neurologic diseases, however, its exact role in vivo is yet to be fully understood. PET imaging enables investigation, quantification, and tracking of different neuroinflammation biomarkers in living subjects longitudinally. One such biomarker that has been imaged extensively using PET is translocator protein 18 kDa (TSPO). Although imaging TSPO has yielded valuable clinical data linking neuroinflammation to various neurodegenerative diseases, considerable limitations of TSPO PET have prompted identification of other more cell-specific and functionally relevant biomarkers. This review analyzes the clinical potential of available and emerging PET biomarkers of innate and adaptive immune responses, with mention of exciting future directions for the field.
AB - Neuroinflammation is a key pathologic hallmark of numerous neurologic diseases, however, its exact role in vivo is yet to be fully understood. PET imaging enables investigation, quantification, and tracking of different neuroinflammation biomarkers in living subjects longitudinally. One such biomarker that has been imaged extensively using PET is translocator protein 18 kDa (TSPO). Although imaging TSPO has yielded valuable clinical data linking neuroinflammation to various neurodegenerative diseases, considerable limitations of TSPO PET have prompted identification of other more cell-specific and functionally relevant biomarkers. This review analyzes the clinical potential of available and emerging PET biomarkers of innate and adaptive immune responses, with mention of exciting future directions for the field.
KW - Biomarker validation
KW - Clinical imaging
KW - Molecular imaging
KW - Neuroinflammation
KW - Positron emission tomography
UR - http://www.scopus.com/inward/record.url?scp=85089128246&partnerID=8YFLogxK
U2 - 10.2967/jnumed.119.229443
DO - 10.2967/jnumed.119.229443
M3 - Article
C2 - 32620705
AN - SCOPUS:85089128246
SN - 0161-5505
VL - 61
SP - 1107
EP - 1112
JO - Journal of Nuclear Medicine
JF - Journal of Nuclear Medicine
IS - 8
ER -