Neuroinflammation pet imaging: Current opinion and future directions

Poorva Jain, Aisling M. Chaney, Mackenzie L. Carlson, Isaac M. Jackson, Anoushka Rao, Michelle L. James

Research output: Contribution to journalArticlepeer-review

59 Scopus citations

Abstract

Neuroinflammation is a key pathologic hallmark of numerous neurologic diseases, however, its exact role in vivo is yet to be fully understood. PET imaging enables investigation, quantification, and tracking of different neuroinflammation biomarkers in living subjects longitudinally. One such biomarker that has been imaged extensively using PET is translocator protein 18 kDa (TSPO). Although imaging TSPO has yielded valuable clinical data linking neuroinflammation to various neurodegenerative diseases, considerable limitations of TSPO PET have prompted identification of other more cell-specific and functionally relevant biomarkers. This review analyzes the clinical potential of available and emerging PET biomarkers of innate and adaptive immune responses, with mention of exciting future directions for the field.

Original languageEnglish
Pages (from-to)1107-1112
Number of pages6
JournalJournal of Nuclear Medicine
Volume61
Issue number8
DOIs
StatePublished - Aug 1 2020

Keywords

  • Biomarker validation
  • Clinical imaging
  • Molecular imaging
  • Neuroinflammation
  • Positron emission tomography

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