Neurofibromatosis Type 1 Mouse Models

Jit Chatterjee; Joshua P. Koleske; David H. Gutmann

doi:10.1007/978-3-031-62945-7_38

Neurofibromatosis Type 1 Mouse Models

Jit Chatterjee, Joshua P. Koleske, David H. Gutmann

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

The development and deployment of Neurofibromatosis type 1 (Nf1) mouse models provides unique opportunities to define the underlying pathogenic causes of specific NF1-associated clinical features, identify potential risk factors for their appearance and progression, and discover new therapies targeted to the responsible cellular and molecular vulnerabilities. Herein, we review the available mouse models for the common medical conditions affecting children and adults with NF1 and discuss the challenges and future directions for their use relevant to improving the care of individuals with this rare neurogenetic syndrome.

Original language	English
Title of host publication	The RASopathies
Subtitle of host publication	Genetic Syndromes of the RAS/MAPK Pathway
Publisher	Springer Nature
Pages	833-854
Number of pages	22
ISBN (Electronic)	9783031629457
ISBN (Print)	9783031629440
DOIs	https://doi.org/10.1007/978-3-031-62945-7_38
State	Published - Jan 1 2024

Keywords

Malignant peripheral nerve sheath tumor
Neurofibroma
Neurofibromin
Optic pathway glioma
Plexiform neurofibroma
RAS

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10.1007/978-3-031-62945-7_38

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abstract = "The development and deployment of Neurofibromatosis type 1 (Nf1) mouse models provides unique opportunities to define the underlying pathogenic causes of specific NF1-associated clinical features, identify potential risk factors for their appearance and progression, and discover new therapies targeted to the responsible cellular and molecular vulnerabilities. Herein, we review the available mouse models for the common medical conditions affecting children and adults with NF1 and discuss the challenges and future directions for their use relevant to improving the care of individuals with this rare neurogenetic syndrome.",

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AB - The development and deployment of Neurofibromatosis type 1 (Nf1) mouse models provides unique opportunities to define the underlying pathogenic causes of specific NF1-associated clinical features, identify potential risk factors for their appearance and progression, and discover new therapies targeted to the responsible cellular and molecular vulnerabilities. Herein, we review the available mouse models for the common medical conditions affecting children and adults with NF1 and discuss the challenges and future directions for their use relevant to improving the care of individuals with this rare neurogenetic syndrome.

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KW - Optic pathway glioma

KW - Plexiform neurofibroma

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Neurofibromatosis Type 1 Mouse Models

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Keywords

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