Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms

Keyphrases

• Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) 100%
• Loss Function 100%
• Neurodegenerative Diseases 100%
• Disease-causing mutations 100%
• Functional Mechanism 100%
• Functional Surface 100%
• Alzheimer's Disease Risk 30%
• Risk Variant 30%
• Cell-based 10%
• Genetic Variants 10%
• Surface Expression 10%
• Genetic Variation 10%
• Functional Studies 10%
• Immune Signaling 10%
• Biophysical Methods 10%
• Variant Proteins 10%
• Nasu-Hakola Disease 10%
• Protein Stability 10%
• Mutation Impact 10%
• Variant Impact 10%
• Epitope Map 10%
• Nasu-Hakola 10%
• Patient-specific Medicine 10%

Medicine and Dentistry

• Degenerative Disease 100%
• Diseases 100%
• Alzheimer's Disease 50%
• Medicine 50%
• Epitope 50%
• Neurodegenerative Disorder 50%
• Genetic Variation 50%
• Protein Variant 50%
• Immune System Receptors 50%
• Protein Stability 50%