Neurodegeneration: A non-apoptotic role for AIF in the brain

Azad Bonni

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations


A recent report provides new insights into the mechanisms of neurodegeneration. In a mouse mutant with progressive cerebellar and retinal degeneration, the expression of the apoptotic protein AIF was found to be downregulated leading paradoxically to apoptosis of neurons that is associated with an imbalance in free radical metabolism and cell cycle re-entry.

Original languageEnglish
Pages (from-to)R19-R21
JournalCurrent Biology
Issue number1
StatePublished - Jan 8 2003


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