Neurocognitive Outcomes and School Performance in Solid Tumor Cancer Survivors Lacking Therapy to the Central Nervous System

Caroline Mohrmann, Jennifer Henry, Marnie Hauff, Robert J. Hayashi

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

School performance in patients who have received therapy for childhood cancers has been studied in depth. Risk factors have historically included cranial radiation, intrathecal chemotherapy, and high doses of chemotherapy, including methotrexate and cytarabine. Leukemia and brain tumor survivors who receive such therapy have been the primary focus of this area of investigation. Extracranial solid tumor cancer patients lacking such risk factors have historically been expected to have normal school performance. We examined the medical records of 58 young pediatric extracranial solid tumor patients who lacked CNS-directed therapy or other known risk factors for cognitive impairment to evaluate the incidence of reported difficulties or abnormalities in neuropsychological testing. Thirty-one percent of patients were found to have at least one reported difficulty or abnormality. Of note, 34% of patients with Wilms tumor possessed difficulties compared to 23% of patients with other extracranial solid tumors. Extracranial solid tumor cancer survivors without known risk factors for school performance difficulties appear to have a higher incidence of problems than expected.

Original languageEnglish
Pages (from-to)83-90
Number of pages8
JournalJournal of Personalized Medicine
Volume5
Issue number2
DOIs
StatePublished - Apr 10 2015

Keywords

  • Neurocognitive
  • Neuropsychological testing
  • School performance
  • Solid tumors
  • Young children

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