TY - JOUR
T1 - Neurobiological Commonalities and Distinctions among Three Major Psychiatric Diagnostic Categories
T2 - A Structural MRI Study
AU - Chang, Miao
AU - Womer, Fay Y.
AU - Edmiston, E. Kale
AU - Bai, Chuan
AU - Zhou, Qian
AU - Jiang, Xiaowei
AU - Wei, Shengnan
AU - Wei, Yange
AU - Ye, Yuting
AU - Huang, Haiyan
AU - He, Yong
AU - Xu, Ke
AU - Tang, Yanqing
AU - Wang, Fei
N1 - Funding Information:
National Natural Science Foundation of China (81271499 and 81571311 to Y.T., 81571331 to F.W.); Liaoning Pandeng Scholar (to F.W.); National Key Research and Development Program (2016YFC0904300 to F. W.); National Key Research and Development Program (2016YFC1306900 to Y.T.); National High Tech Development Plan (863) (2015AA020513 to F.W.).
Publisher Copyright:
© The Author 2017. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved.
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Background: Schizophrenia (SZ), bipolar disorder (BD), and major depressive disorder (MDD) are distinct diagnostic categories in current psychiatric nosology, yet there is increasing evidence for shared clinical and biological features in these disorders. No previous studies have examined brain structural features concurrently in these 3 disorders. The aim of this study was to identify the extent of shared and distinct brain alterations in SZ, BD, and MDD. We examined gray matter (GM) volume and white matter (WM) integrity in a total of 485 individuals (135 with SZ, 86 with BD, 108 with MDD, and 156 healthy controls [HC]) who underwent high-resolution structural magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) at a single site. Results: Significant 4-group (SZ, BD, MDD, and HC groups) differences (P <.05, corrected) in GM volumes were found primarily in the paralimbic and heteromodal corticies. Post hoc analyses showed that the SZ, BD, and MDD groups shared GM volume decreases in 87.9% of the total regional volume with significant 4-group differences. Significant 4-group differences in WM integrity (P <.05 corrected) were found in callosal, limbic-paralimbic-hetermodal, cortico-cortical, thalamocortical and cerebellar WM. Post hoc analyses revealed that the SZ and BD groups shared WM alterations in all regions, while WM alterations were not observed with MDD. Conclusions: Our findings of common alterations in SZ, BD, and MDD support the presence of core neurobiological disruptions in these disorders and suggest that neural structural distinctions between these disorders may be less prominent than initially postulated, particularly between SZ and BD.
AB - Background: Schizophrenia (SZ), bipolar disorder (BD), and major depressive disorder (MDD) are distinct diagnostic categories in current psychiatric nosology, yet there is increasing evidence for shared clinical and biological features in these disorders. No previous studies have examined brain structural features concurrently in these 3 disorders. The aim of this study was to identify the extent of shared and distinct brain alterations in SZ, BD, and MDD. We examined gray matter (GM) volume and white matter (WM) integrity in a total of 485 individuals (135 with SZ, 86 with BD, 108 with MDD, and 156 healthy controls [HC]) who underwent high-resolution structural magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) at a single site. Results: Significant 4-group (SZ, BD, MDD, and HC groups) differences (P <.05, corrected) in GM volumes were found primarily in the paralimbic and heteromodal corticies. Post hoc analyses showed that the SZ, BD, and MDD groups shared GM volume decreases in 87.9% of the total regional volume with significant 4-group differences. Significant 4-group differences in WM integrity (P <.05 corrected) were found in callosal, limbic-paralimbic-hetermodal, cortico-cortical, thalamocortical and cerebellar WM. Post hoc analyses revealed that the SZ and BD groups shared WM alterations in all regions, while WM alterations were not observed with MDD. Conclusions: Our findings of common alterations in SZ, BD, and MDD support the presence of core neurobiological disruptions in these disorders and suggest that neural structural distinctions between these disorders may be less prominent than initially postulated, particularly between SZ and BD.
KW - bipolar disorder
KW - gray matter volume
KW - major depressive disorder
KW - schizophrenia
KW - white matter integrity
UR - http://www.scopus.com/inward/record.url?scp=85040834766&partnerID=8YFLogxK
U2 - 10.1093/schbul/sbx028
DO - 10.1093/schbul/sbx028
M3 - Article
C2 - 29036668
AN - SCOPUS:85040834766
VL - 44
SP - 65
EP - 74
JO - Schizophrenia Bulletin
JF - Schizophrenia Bulletin
SN - 0586-7614
IS - 1
ER -