TY - JOUR
T1 - Neural Correlates of Response Inhibition in Adolescents Prospectively Predict Regular Tobacco Smoking
AU - Anokhin, Andrey P.
AU - Golosheykin, Simon
N1 - Funding Information:
National Institutes of Health: DA00421, DA027096, DA018899.
Publisher Copyright:
© 2016 Taylor & Francis.
PY - 2016/2/17
Y1 - 2016/2/17
N2 - Inhibitory deficits have been widely reported in addiction; however, it remains unclear whether such deficits represent a determinant or a consequence of substance use. Here we show, using a prospective longitudinal design, that developmental abnormalities in the neural correlates of response inhibition in adolescents increase the risk for subsequent cigarette smoking. Reduced No-Go P3 amplitude, delayed latency of Go P3 peak, and reduced synchrony of neuronal oscillations at age 14 prospectively predicted regular smoking at age 18. The present findings suggest that functional brain correlates of response inhibition represent a developmental marker of risk for future substance abuse.
AB - Inhibitory deficits have been widely reported in addiction; however, it remains unclear whether such deficits represent a determinant or a consequence of substance use. Here we show, using a prospective longitudinal design, that developmental abnormalities in the neural correlates of response inhibition in adolescents increase the risk for subsequent cigarette smoking. Reduced No-Go P3 amplitude, delayed latency of Go P3 peak, and reduced synchrony of neuronal oscillations at age 14 prospectively predicted regular smoking at age 18. The present findings suggest that functional brain correlates of response inhibition represent a developmental marker of risk for future substance abuse.
UR - http://www.scopus.com/inward/record.url?scp=84978115975&partnerID=8YFLogxK
U2 - 10.1080/87565641.2016.1195833
DO - 10.1080/87565641.2016.1195833
M3 - Article
C2 - 27392089
AN - SCOPUS:84978115975
VL - 41
SP - 22
EP - 37
JO - Developmental Neuropsychology
JF - Developmental Neuropsychology
SN - 8756-5641
IS - 1-2
ER -