TY - JOUR
T1 - Neural Correlates of Novelty-Evoked Distress in 4-Month-Old Infants
T2 - A Synthetic Cohort Study
AU - Filippi, Courtney A.
AU - Winkler, Anderson M.
AU - Kanel, Dana
AU - Elison, Jed T.
AU - Hardiman, Hannah
AU - Sylvester, Chad
AU - Pine, Daniel S.
AU - Fox, Nathan A.
N1 - Publisher Copyright:
© 2024 Society of Biological Psychiatry
PY - 2024/9
Y1 - 2024/9
N2 - Background: Observational assessments of infant temperament have provided unparalleled insight into prediction of risk for social anxiety. However, it is challenging to administer and score these assessments alongside high-quality infant neuroimaging data. In the current study, we aimed to identify infant resting-state functional connectivity associated with both parent report and observed behavioral estimates of infant novelty-evoked distress. Methods: Using data from the OIT (Origins of Infant Temperament) study, which includes deep phenotyping of infant temperament, we identified parent-report measures that were associated with observed novelty-evoked distress. These parent-report measures were then summarized into a composite score used for imaging analysis. Our infant magnetic resonance imaging sample was a synthetic cohort, harmonizing data from 2 functional magnetic resonance imaging studies of 4-month-old infants (OIT and BCP [Baby Connectome Project]; n = 101), both of which included measures of parent-reported temperament. Brain-behavior associations were evaluated using enrichment, a statistical approach that quantifies the clustering of brain-behavior associations within network pairs. Results: Results demonstrated that parent-report composites of novelty-evoked distress were significantly associated with 3 network pairs: dorsal attention–salience/ventral attention, dorsal attention–default mode, and dorsal attention–control. These network pairs demonstrated negative associations with novelty-evoked distress, indicating that less connectivity between these network pairs was associated with greater novelty-evoked distress. Additional analyses demonstrated that dorsal attention–control network connectivity was associated with observed novelty-evoked distress in the OIT sample (n = 38). Conclusions: Overall, this work is broadly consistent with existing work and implicates dorsal attention network connectivity in novelty-evoked distress. This study provides novel data on the neural basis of infant novelty-evoked distress.
AB - Background: Observational assessments of infant temperament have provided unparalleled insight into prediction of risk for social anxiety. However, it is challenging to administer and score these assessments alongside high-quality infant neuroimaging data. In the current study, we aimed to identify infant resting-state functional connectivity associated with both parent report and observed behavioral estimates of infant novelty-evoked distress. Methods: Using data from the OIT (Origins of Infant Temperament) study, which includes deep phenotyping of infant temperament, we identified parent-report measures that were associated with observed novelty-evoked distress. These parent-report measures were then summarized into a composite score used for imaging analysis. Our infant magnetic resonance imaging sample was a synthetic cohort, harmonizing data from 2 functional magnetic resonance imaging studies of 4-month-old infants (OIT and BCP [Baby Connectome Project]; n = 101), both of which included measures of parent-reported temperament. Brain-behavior associations were evaluated using enrichment, a statistical approach that quantifies the clustering of brain-behavior associations within network pairs. Results: Results demonstrated that parent-report composites of novelty-evoked distress were significantly associated with 3 network pairs: dorsal attention–salience/ventral attention, dorsal attention–default mode, and dorsal attention–control. These network pairs demonstrated negative associations with novelty-evoked distress, indicating that less connectivity between these network pairs was associated with greater novelty-evoked distress. Additional analyses demonstrated that dorsal attention–control network connectivity was associated with observed novelty-evoked distress in the OIT sample (n = 38). Conclusions: Overall, this work is broadly consistent with existing work and implicates dorsal attention network connectivity in novelty-evoked distress. This study provides novel data on the neural basis of infant novelty-evoked distress.
KW - Anxiety
KW - Attention
KW - Connectivity
KW - Infancy
KW - Resting-state fMRI
KW - Temperament
UR - http://www.scopus.com/inward/record.url?scp=85196965405&partnerID=8YFLogxK
U2 - 10.1016/j.bpsc.2024.03.008
DO - 10.1016/j.bpsc.2024.03.008
M3 - Article
C2 - 38641209
AN - SCOPUS:85196965405
SN - 2451-9022
VL - 9
SP - 905
EP - 914
JO - Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
JF - Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
IS - 9
ER -