TY - JOUR
T1 - Neural correlates of global and specific cognitive deficits in schizophrenia
AU - Jirsaraie, Robert J.
AU - Sheffield, Julia M.
AU - Barch, Deanna M.
N1 - Funding Information:
RJJ has no conflicts to report. JMS has no conflicts to report. DMB has received grants from the Brain & Behavior Research Foundation and the National Institutes of Health (NIH), and is a consultant for Pfizer, Amgen, Upsher-Smith and Takeda on studies related to the treatment of negative symptoms in schizophrenia.
Funding Information:
The data for use in this paper came from the RDoC Database housed by the NIH, and was generated by the Bipolar and Schizophrenia Consortium for Parsing Intermediate Phenotype study (B-SNIP 1). The DOI is:10.15154/1375730, Data used in the preparation of this article reside in the NIH-supported NIMH Data Repositories in [DOI:10.15154/1375730]. We wish to thank the Principal Investigators of the Bipolar and Schizophrenia Consortium for Parsing Intermediate Phenotypes. We would like to give a special thanks to Rochelle Smith and Mitchell Sommers, PhD, for acquiring a training grant from the Leadership Alliance Early-Identification Program, which contributed to the development of this project.
Funding Information:
Data used in the preparation of this article reside in the NIH-supported NIMH Data Repositories in [DOI: 10.15154/1375730 ]. We wish to thank the Principal Investigators of the Bipolar and Schizophrenia Consortium for Parsing Intermediate Phenotypes. We would like to give a special thanks to Rochelle Smith and Mitchell Sommers, PhD, for acquiring a training grant from the Leadership Alliance Early-Identification Program, which contributed to the development of this project.
Publisher Copyright:
© 2018 Elsevier B.V.
PY - 2018/11
Y1 - 2018/11
N2 - Cognitive deficits are a core feature of schizophrenia, but the neural mechanisms that contribute to these characteristics are not fully understood. This study investigated whether volume of the dorsal lateral prefrontal cortex (DLPFC), inferior frontal gyrus (IFG), hippocampus, and white matter were associated with impairment in specific cognitive domains, including executive functioning, working memory, verbal memory, verbal fluency, processing speed, versus global functioning. The multi-site data used in this study was collected from the Bipolar and Schizophrenia Network on Intermediate Phenotypes (B-SNIP), and consisted of 206 healthy controls and 247 individuals with either schizophrenia or schizoaffective disorder. The neuroimaging data was segmented based on the Destrieux atlas in FreeSurfer. Linear regression analyses revealed that global cognition, executive functioning, working memory, and processing speed were associated with all brain structures, except the DLPFC was only associated with executive fucntion. When controlling for the global cognitive deficit, executive function was trending significance with white matter, but continued to be associated with the DLPFC and IFG, as did the association between processing speed and the hippocampus. These findings suggest that volumes of the DLPFC, IFG, hippocampus, and white matter are associated with the global cognitive impairment seen in schizophrenia, but some brain structures may also be specifically related to domain-specific deficits (primarily executive function) over-and-beyond the global cognitive deficit.
AB - Cognitive deficits are a core feature of schizophrenia, but the neural mechanisms that contribute to these characteristics are not fully understood. This study investigated whether volume of the dorsal lateral prefrontal cortex (DLPFC), inferior frontal gyrus (IFG), hippocampus, and white matter were associated with impairment in specific cognitive domains, including executive functioning, working memory, verbal memory, verbal fluency, processing speed, versus global functioning. The multi-site data used in this study was collected from the Bipolar and Schizophrenia Network on Intermediate Phenotypes (B-SNIP), and consisted of 206 healthy controls and 247 individuals with either schizophrenia or schizoaffective disorder. The neuroimaging data was segmented based on the Destrieux atlas in FreeSurfer. Linear regression analyses revealed that global cognition, executive functioning, working memory, and processing speed were associated with all brain structures, except the DLPFC was only associated with executive fucntion. When controlling for the global cognitive deficit, executive function was trending significance with white matter, but continued to be associated with the DLPFC and IFG, as did the association between processing speed and the hippocampus. These findings suggest that volumes of the DLPFC, IFG, hippocampus, and white matter are associated with the global cognitive impairment seen in schizophrenia, but some brain structures may also be specifically related to domain-specific deficits (primarily executive function) over-and-beyond the global cognitive deficit.
KW - Brain volume
KW - Cognitive deficits
KW - Dorsolateral prefrontal cortex
KW - Hippocampus
KW - Structural MRI
KW - White matter
UR - https://www.scopus.com/pages/publications/85048934966
U2 - 10.1016/j.schres.2018.06.017
DO - 10.1016/j.schres.2018.06.017
M3 - Article
C2 - 29954699
AN - SCOPUS:85048934966
SN - 0920-9964
VL - 201
SP - 237
EP - 242
JO - Schizophrenia research
JF - Schizophrenia research
ER -